Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. C overing the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms…mehr
Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens.
C overing the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes.
Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.
Alan D.T. Barrett, Ph.D., Professor, Department of Pathology, John D. Stobo, M.D. Chair in Vacinology and Director, Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, Texas, USA Gregg N. Milligan, Professor, Department of Pediatrics and Senior Scientist, Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, Texas, USA
Inhaltsangabe
Contributors vii Preface ix 1 The history of vaccine development and the diseases vaccines prevent 1 Martin G. Myers 2 The vaccine development pathway 33 David W.C. Beasley 3 Control and eradication of human and animal diseases by vaccination 43 Nigel Bourne and Gregg N. Milligan 4 Pathogenesis of infectious diseases and mechanisms of immunity 59 Jere W. McBride and David H. Walker 5 The host immune response protective immunity and correlates of protection 73 Gregg N. Milligan 6 Adjuvants: making vaccines immunogenic 93 Gregg N. Milligan 7 Discovery and the basic science phase of vaccine development 109 Gavin C. Bowick 8 Microbial-based and material-based vaccine delivery systems 127 Alfredo G. Torres, Jai S. Rudra and Gregg N. Milligan 9 Licensed vaccines for humans 152 Alan D.T. Barrett 10 Veterinary vaccines 181 A. Paige Adams 11 Development of vaccines for microbial diseases 192 Dennis W. Trent and David W.C. Beasley 12 The regulatory path to vaccine licensure 212 Dennis W. Trent 13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232 A. Paige Adams 14 Vaccine manufacturing 243 Dirk E. Teuwen and Alan D.T. Barrett 15 Clinical evaluation of vaccines 260 Richard E. Rupp and Bridget E. Hawkins 16 Vaccine recommendations and special populations 273 Richard E. Rupp and Bridget E. Hawkins 17 Vaccine safety 287 Dirk E. Teuwen and Alan D.T. Barrett 18 Understanding and measuring the dynamics of infectious disease transmission 304 Christine M. Arcari 19 Vaccines from a global perspective 319 Alan D.T. Barrett and Bridget E. Hawkins 20 Political ethical social and psychological aspects of vaccinology 335 Caroline M. Poland, Robert M. Jacobson, Douglas J. Opel, Edgar K. Marcuse and Gregory A. Poland Index 358
Contributors vii Preface ix 1 The history of vaccine development and the diseases vaccines prevent 1 Martin G. Myers 2 The vaccine development pathway 33 David W.C. Beasley 3 Control and eradication of human and animal diseases by vaccination 43 Nigel Bourne and Gregg N. Milligan 4 Pathogenesis of infectious diseases and mechanisms of immunity 59 Jere W. McBride and David H. Walker 5 The host immune response protective immunity and correlates of protection 73 Gregg N. Milligan 6 Adjuvants: making vaccines immunogenic 93 Gregg N. Milligan 7 Discovery and the basic science phase of vaccine development 109 Gavin C. Bowick 8 Microbial-based and material-based vaccine delivery systems 127 Alfredo G. Torres, Jai S. Rudra and Gregg N. Milligan 9 Licensed vaccines for humans 152 Alan D.T. Barrett 10 Veterinary vaccines 181 A. Paige Adams 11 Development of vaccines for microbial diseases 192 Dennis W. Trent and David W.C. Beasley 12 The regulatory path to vaccine licensure 212 Dennis W. Trent 13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232 A. Paige Adams 14 Vaccine manufacturing 243 Dirk E. Teuwen and Alan D.T. Barrett 15 Clinical evaluation of vaccines 260 Richard E. Rupp and Bridget E. Hawkins 16 Vaccine recommendations and special populations 273 Richard E. Rupp and Bridget E. Hawkins 17 Vaccine safety 287 Dirk E. Teuwen and Alan D.T. Barrett 18 Understanding and measuring the dynamics of infectious disease transmission 304 Christine M. Arcari 19 Vaccines from a global perspective 319 Alan D.T. Barrett and Bridget E. Hawkins 20 Political ethical social and psychological aspects of vaccinology 335 Caroline M. Poland, Robert M. Jacobson, Douglas J. Opel, Edgar K. Marcuse and Gregory A. Poland Index 358
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