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C-reactive protein is an important complement in determining the local and systemic inflammatory state. In the presence of infectious states it can reach significant values. An observational, descriptive and cross-sectional study was carried out in 52 patients with a diagnosis of Odontogenic Facial Cellulitis admitted to the Maxillofacial Surgery service of the "Saturnino Lora Torres" Provincial Clinical-Surgical Teaching Hospital in Santiago de Cuba, in the period between 1 August 2016 and July 31, 2018, in order to identify variations in the levels of c-reactive protein. Variations in c-reactive protein during and after specific treatment were identified in patients with Odontogenic Facial Cellulitis, which decreases proportionally with the results of the evolution of the patients, considering it as a weapon for understanding the immune status in short periods of time.