Substantial relief of discomfort may be anticipated by most patients suffering from pelvic and lower-extremity pain who are treated by arterial infusion of nitrogen mustard. Seventy-three patients with intractable pain secondary to malignancy arising in the pelvis received 83 percutaneous pelvic arterial infusions of this drug. Sixty infusions (72%) resulted in marked relief from pain for periods averaging 6-8 weeks. Advantages of the procedure are low toxicity, relative simplicity and availability of technique, and an acceptable rate of complications with minimal morbidity. Patients…mehr
Substantial relief of discomfort may be anticipated by most patients suffering from pelvic and lower-extremity pain who are treated by arterial infusion of nitrogen mustard. Seventy-three patients with intractable pain secondary to malignancy arising in the pelvis received 83 percutaneous pelvic arterial infusions of this drug. Sixty infusions (72%) resulted in marked relief from pain for periods averaging 6-8 weeks. Advantages of the procedure are low toxicity, relative simplicity and availability of technique, and an acceptable rate of complications with minimal morbidity. Patients experiencing satisfactory results may expect significant relief from a second infusion for recurrent pain. The most rewarding result is the freedom from the cyclic return of pain characterized by oral and intramuscular analgesic therapy. Little or no relief can be expected in patients with pain caused by compression fractures of the vertebrae, or where the tumor burden is so great that adequate perfusion of the involved nerves is not possible. One should consider this procedure for controlling pain before resorting to the more dangerous and potentially disabling techniques of spinal cordotomy or intrathecal alcohol injection. References Bateman JR, Hazen JG, Stolinsky DC, Steinfeld JL (1966) Advanced carcinoma of the cervix treated by intra-arterial methotrexate. Am J Obstet Gynecol 96: 181-187 Calabresi P, Parks RW Jr (1970) Alkylating agents, antimetabolites, hormones. and other antiproliferative agents. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 4th edn.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Selective Embolization and Organ Perfusion with Cytostatics.- Pharmacokinetics of Intra-Arterial Chemotherapy.- Infusion Chemotherapy in Inoperable Pancreatic Carcinoma.- Intra-Arterial Infusion in Tumors of the Pelvis.- The Use of Nitrogen Mustard in the Treatment of Intractable Pelvic Pain.- Intra-Arterial Perfusion Therapy with 5-Fluorouracil in Patients with Metastatic Colorectal Carcinoma and Intractable Pelvic Pain.- Palliative Therapy of Pelvic Tumors by Intra-Arterial Infusion of Cytotoxic Drugs.- Catheter Embolization in the Central Nervous System and the Gastrointestinal Tract.- Percutaneous Embolization of Urological Tumors.- Chemoembolization: A New Treatment for Malignant Tumors and Metastases.- Discussion.- Intra-Arterial Liver Perfusion.- Prolonged and Continuous Percutaneous Intra-Arterial Hepatic Infusion Chemotherapy in Advanced Metastatic Liver Adenocarcinoma from Colorectal Primary.- Arterial Infusion Chemotherapy for Hepatic Metastases.- Transient Repeated Dearterialization Combined with Intra-Arterial Infusion of Oncolytic Drugs in the Treatment of Liver Tumors.- Intra-Arterial Chemotherapy of the Liver with Transient, Repeated Hypoxia.- Intrahepatic Chemotherapy in Isolated Liver Metastases.- Improved Quality of Life with an Implantable Pump for Liver Perfusion.- Catheterization of the Portal Vein by the Transumbilical Approach for Intrahepatic Chemotherapy.- Discussion.- Isolated Liver Perfusion.- Isolated Liver Perfusion in Dogs.- First Experimental and Clinical Results of Isolated Liver Perfusion with Cytotoxics in Metastases from Colorectal Primary.- Ultrastructural Changes in the Dog Liver Cell After Isolated Liver Perfusion with Various Cytotoxins.- Anesthesia for Isolated Liver Perfusion in Man.- Kinetics of Methotrexate, Dacarbazine and 5-Fluorouracil During Isolated Liver Perfusion.- Discussion.- Selective Organ Perfusion with Cytostatics.- Clinical Experience in the Use of Intra-Arterial Infusion Chemotherapy in the Treatment of Cancers in the Head and Neck, the Extremities, the Breast and the Stomach.- Intra-Arterial Infusion Therapy for Pulmonary Tumours.- Scintigraphic Documentation of Lymph Drainage of Cutaneous Tumours.- Kinetics of 57Co-Bleomycin in Sheep After Intra-Arterial Injection in the Head and Neck Region.- Combined Treatment of Maxillofacial Carcinoma by Intra-Arterial Proliferation Block and Irradiation.- Intracarotid Artery Infusion of DTIC for Invasive Maxillofacial Melanoma.- Combined Multimodality (Surgery, Radiotherapy, Intra-Arterial Chemotherapy) Treatment of Advanced Carcinoma of Paranasal Sinuses.- A Special Method of Intra-Arterial Infusion for Treatment of Head and Neck Cancer.- Indications and Counterindications of Intra-Arterial Chemotherapy of Head and Neck Tumors.- Tumortherapy with Hyperthermia.- Basic Principles in Hyperthermic Tumor Therapy.- Therapy of Fibrosarcoma in the Rectum of Rats by Selective Hyperthermia.- Vascular Perfusion in Cancer Therapy of the Extremities.- Chemotherapy by Isolated Regional Perfusion for Melanoma of the Limbs.- Intra-Arterial Infusion of Bromodeoxyuridine and Radiotherapy in Osteosarcoma and Other Bone Malignancies.- Super-Selective Cytostatic Treatment of Malignant Tumors of the Soft Tissue and Bone.- Tourniquet Infusion with DTIC in Therapy-Resistant Melanoma on the Extremities: A Pilot Study.- Intra-Arterial Adriamycin for Limb Sarcomas.- Discussion.- Isolated Perfusion of the Extremities.- Hyperthermic Regional Perfusion in High-Risk Stage-I Malignant Melanomas of the Extremities.- Hyperthermic Perfusion in Malignant Melanoma: 5-YearResults.- Regional Perfusion with cis-Platinum and Dacarbazine.- Fluorescence-Histochemical and Electron-Microscopical Investigations in Melanoma Patients After Isolated Cytostatic Perfusion.- Tissue Toxicity in Experimental Isolated Perfusion with Adriamycin.- Regional Perfusion with Adriamycin in Soft Tissue Sarcomas.- Peripheral Nerve Damage Following Isolated Extremity Perfusion with cis-Platinum.- Objective Regression of Unexcised Melanoma in-Transit Metastases After Hyperthermic Isolation Perfusion of the Limbs with Melphalan.- Results of Regional Hyperthermic Perfusion for Primary and Recurrent Melanomas of the Extremities.- First Histologic Findings in Metastases of Colorectal Carcinoma Following Isolated Liver Perfusion with Cytostatics.
Selective Embolization and Organ Perfusion with Cytostatics.- Pharmacokinetics of Intra-Arterial Chemotherapy.- Infusion Chemotherapy in Inoperable Pancreatic Carcinoma.- Intra-Arterial Infusion in Tumors of the Pelvis.- The Use of Nitrogen Mustard in the Treatment of Intractable Pelvic Pain.- Intra-Arterial Perfusion Therapy with 5-Fluorouracil in Patients with Metastatic Colorectal Carcinoma and Intractable Pelvic Pain.- Palliative Therapy of Pelvic Tumors by Intra-Arterial Infusion of Cytotoxic Drugs.- Catheter Embolization in the Central Nervous System and the Gastrointestinal Tract.- Percutaneous Embolization of Urological Tumors.- Chemoembolization: A New Treatment for Malignant Tumors and Metastases.- Discussion.- Intra-Arterial Liver Perfusion.- Prolonged and Continuous Percutaneous Intra-Arterial Hepatic Infusion Chemotherapy in Advanced Metastatic Liver Adenocarcinoma from Colorectal Primary.- Arterial Infusion Chemotherapy for Hepatic Metastases.- Transient Repeated Dearterialization Combined with Intra-Arterial Infusion of Oncolytic Drugs in the Treatment of Liver Tumors.- Intra-Arterial Chemotherapy of the Liver with Transient, Repeated Hypoxia.- Intrahepatic Chemotherapy in Isolated Liver Metastases.- Improved Quality of Life with an Implantable Pump for Liver Perfusion.- Catheterization of the Portal Vein by the Transumbilical Approach for Intrahepatic Chemotherapy.- Discussion.- Isolated Liver Perfusion.- Isolated Liver Perfusion in Dogs.- First Experimental and Clinical Results of Isolated Liver Perfusion with Cytotoxics in Metastases from Colorectal Primary.- Ultrastructural Changes in the Dog Liver Cell After Isolated Liver Perfusion with Various Cytotoxins.- Anesthesia for Isolated Liver Perfusion in Man.- Kinetics of Methotrexate, Dacarbazine and 5-Fluorouracil During Isolated Liver Perfusion.- Discussion.- Selective Organ Perfusion with Cytostatics.- Clinical Experience in the Use of Intra-Arterial Infusion Chemotherapy in the Treatment of Cancers in the Head and Neck, the Extremities, the Breast and the Stomach.- Intra-Arterial Infusion Therapy for Pulmonary Tumours.- Scintigraphic Documentation of Lymph Drainage of Cutaneous Tumours.- Kinetics of 57Co-Bleomycin in Sheep After Intra-Arterial Injection in the Head and Neck Region.- Combined Treatment of Maxillofacial Carcinoma by Intra-Arterial Proliferation Block and Irradiation.- Intracarotid Artery Infusion of DTIC for Invasive Maxillofacial Melanoma.- Combined Multimodality (Surgery, Radiotherapy, Intra-Arterial Chemotherapy) Treatment of Advanced Carcinoma of Paranasal Sinuses.- A Special Method of Intra-Arterial Infusion for Treatment of Head and Neck Cancer.- Indications and Counterindications of Intra-Arterial Chemotherapy of Head and Neck Tumors.- Tumortherapy with Hyperthermia.- Basic Principles in Hyperthermic Tumor Therapy.- Therapy of Fibrosarcoma in the Rectum of Rats by Selective Hyperthermia.- Vascular Perfusion in Cancer Therapy of the Extremities.- Chemotherapy by Isolated Regional Perfusion for Melanoma of the Limbs.- Intra-Arterial Infusion of Bromodeoxyuridine and Radiotherapy in Osteosarcoma and Other Bone Malignancies.- Super-Selective Cytostatic Treatment of Malignant Tumors of the Soft Tissue and Bone.- Tourniquet Infusion with DTIC in Therapy-Resistant Melanoma on the Extremities: A Pilot Study.- Intra-Arterial Adriamycin for Limb Sarcomas.- Discussion.- Isolated Perfusion of the Extremities.- Hyperthermic Regional Perfusion in High-Risk Stage-I Malignant Melanomas of the Extremities.- Hyperthermic Perfusion in Malignant Melanoma: 5-YearResults.- Regional Perfusion with cis-Platinum and Dacarbazine.- Fluorescence-Histochemical and Electron-Microscopical Investigations in Melanoma Patients After Isolated Cytostatic Perfusion.- Tissue Toxicity in Experimental Isolated Perfusion with Adriamycin.- Regional Perfusion with Adriamycin in Soft Tissue Sarcomas.- Peripheral Nerve Damage Following Isolated Extremity Perfusion with cis-Platinum.- Objective Regression of Unexcised Melanoma in-Transit Metastases After Hyperthermic Isolation Perfusion of the Limbs with Melphalan.- Results of Regional Hyperthermic Perfusion for Primary and Recurrent Melanomas of the Extremities.- First Histologic Findings in Metastases of Colorectal Carcinoma Following Isolated Liver Perfusion with Cytostatics.
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