Mosquitoes are a vector agent that carries mosquito-borne disease, transmitting viruses and parasites from person to person without catching the disease themselves. Interactions between the bacterial pathogens and the mosquito mid-gut are complex and often antagonistic. The molecular basis for parasite¿mosquito recognition during mid-gut invasion and the mechanisms by which mosquito defenses against the parasite are induced are the research of interest. The understanding of these processes may lead to the development of novel approaches for disease control.