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Angiogenesis is the complex process of formation of new blood vessels from the pre-existing vasculature in the postnatal life. Studies reported that targeting angiogenesis is considered a useful therapeutic approach in a number of pathological conditions including cancer. This book provides an overview of VEGF-A mediated angiogenic signaling. This monograph may also be considered as a primary reference material for both clinicians and academicians, for getting a flavor of VEGF-A/VEGFR-2 mediated signaling in angiogenesis.