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High Quality Content by WIKIPEDIA articles! Vein graft disease is a generic reference to the pregressive degradation and build up atheroma and clots within the ever thickening wall of veins which are used as arteries during surgical bypass operations. Often, over days to less than a decade, the sections of veins which are used as bypass graphs (sewn into the side of arteries as another path for blood to flow through) deform, narrow and occlude.