Vaccines are an important tool for halting the spread of the pandemic such as COVID-19 influenza. An additional primary shot of a COVID-19 vaccine is recommended for people who are vaccinated and might not have had a strong enough immune response. Information about attitudes toward third vaccine doses could inform the design of health communication messages for more hesitant groups. Delving into understanding the Perspectives of Valley View University Students in Ghana on COVID-19 Vaccine Booster, this study scrutinizes the landscape of COVID-19 vaccine booster acceptance. The study has the potential to contribute to the broader efforts to combat the COVID-19 pandemic by providing insights that can be used to enhance vaccination acceptance and uptake among Valley View University students and potentially similar demographics in Ghana and beyond.