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Vine Street functions as Cincinnati's central thorough-fare. It bisects the downtown and Over-the-Rhine neighborhoods. The street also serves as the dividing line for the "east" and "west" sides of the city. All east-west addresses in the city start at zero at Vine Street. It heads mostly north-northeast from the riverfront area through the Over-the-Rhine neighborhood, ascending between Fairview and Mount Auburn until it courses the uptown plateau past the University of Cincinnati. As the eastern perimeter of the campus and the Environmental Protection Agency's regional offices, Vine is called Jefferson Avenue, though it directly connects with Vine Street on its north and south ends. An adjunct, known as Short Vine, essentially parallels Jefferson Avenue and functions as a central artery of the neighborhood of Corryville, an off-campus business district with a number of shops, music venues, and restaurants.