Viral Nanotechnology

Herausgeber: Khudyakov, Yury; Pumpens, Paul

• Gebundenes Buch

Produktbeschreibung

This book presents a review of a rapidly developing field of viral nanotechnology in the context of immunology, virology, microbiology, chemistry, physics, and mathematical modeling. Viral nanotechnology is founded on the unexpected properties of viral nanoparticles. It emphasizes applications of viral nanotechnology to improving health and advancing material technologies. These applications include developing vaccines for prevention of disease, developing drugs and genetic therapies for treatment of disease, and developing diagnostic reagents and novel imaging technologies for detecting disease and infectious agents causing disease.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 524
• Erscheinungstermin: 23. Juni 2015
• Englisch
• Abmessung: 287mm x 224mm x 35mm
• Gewicht: 1896g
• ISBN-13: 9781466583528
• ISBN-10: 1466583525
• Artikelnr.: 42527784

Autorenporträt

Yury Khudyakov, PhD, received his MS in genetics from Novosibirsk State University and his PhD in molecular biology from the D.I. Ivanovsky Institute of Virology, Academy of Medical Sciences in Russia. He is chief of the Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia. He has published more than 170 research papers and book chapters, is an author of several issued and pending patents, and is a member of the editorial board for the Journal of Clinical Virology and academic editor for PlosOne. Paul Pumpens graduated from the Chemical Department of the University of Latvia in 1970, received his PhD in molecular biology from the Latvian Academy of Sciences in Riga, and received his DSc from the Institute of Molecular Biology of the USSR Academy of Sciences in Moscow. He pioneered genetic engineering research in Latvia and was one of the first in the world to successfully clone the hepatitis B virus genome. He is an author of more than 300 scientific papers and issued or pending patents.

Inhaltsangabe

Preface. Editors. Contributors. Introduction. Introduction to Capsid
Architecture. Self-Assembling Virus-like and Virus-Unlike Particles.
Electron Cryomicroscopy and Image Reconstruction of Viral Nanoparticles.
X-Ray Analysis of Viral Nanoparticles. Computational Methods for
Engineering Protein 3D Nanoobjects. Viral Nanoparticles: Principles of
Construction and Characterization. Immunology of Virus-like Particles.
Nanomedicine: General Considerations and Examples. Virus-like Particles: A
Versatile Tool for Basic and Applied Research on Emerging and Reemerging
Viruses. Virus-like Particles Derived from Hepatitis Viruses. History and
Potential of Hepatitis B Virus Core as a VLP Vaccine Platform. SplitCore:
Advanced Nanoparticulate Molecular Presentation Platform Based on the
Hepatitis B Virus Capsid. Use of VLPs in the Design of Malaria Vaccines.
Use of HBcAg as an Adjuvant in DNA-Based Vaccines: An Unexpected Journey.
Bacteriophage Virus-like Particles as a Platform for Vaccine Discovery.
Production of Virus-like Particles in Plants. Bionanomaterials from Plant
Viruses. Assembly of Bluetongue Virus-like Particle: Multiprotein Complex
and Its Use as Vaccine. Virus-like Particles Based on Polyomaviruses and
Human Papillomaviruses as Vectors for Vaccines, Preventive and Therapeutic
Immunotherapy, and Gene Delivery. Applications of Viral Nanoparticles Based
on Polyomavirus and Papillomavirus Structures. Nanoparticles of Norovirus.
Virus-like Particle Enzyme Encapsulation: Confined Catalysts and Metabolic
Materials. Principles of Design of Virus Nanoparticles for Imaging
Application. Enveloped Viruses with Single-Stranded Negative RNA Genome as
Objects and Subjects of VLP Nanotechnology. Traditional and Novel Trends in
Influenza Vaccines. Retrovirus-Derived Virus-like Particles. Cancer Therapy
Applying Viral Nanoparticles. Alphaviral Vectors for Cancer Treatment.
Synthetic Virus-like Particles in Vaccine Design. Index.