Peter Moore

Visualizing the Invisible

Imaging Techniques for the Structural Biologist

• Gebundenes Buch

Produktbeschreibung

Imaging of Biological Materials presents the four most important approaches to the imaging of biological structures: crystallography, non-crystallographic diffraction, optical microscopy, and electron microscopy.

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The objective of this textbook is to introduce its readers to the many techniques now available for imaging biological materials, e.g. crystallography, optical microscopy and electron microscopy, at a level that will enable them to use them effectively to do research. Since all of these experimental methods are best understood in terms of Fourier transformations, this book explains the relevant concepts from this branch of mathematics, and then illustrates their elegance and power by applying them to each of the techniques presented.

Produktdetails

• Verlag: Oxford University Press, USA
• Seitenzahl: 384
• Erscheinungstermin: 2. April 2012
• Englisch
• Abmessung: 236mm x 155mm x 25mm
• Gewicht: 680g
• ISBN-13: 9780199767090
• ISBN-10: 0199767092
• Artikelnr.: 34157963

Autorenporträt

Peter Moore is a biophysical chemist who got his Ph.D. at Harvard with J.D. Watson, and spent most of his subsequent career at Yale. He is best known for his work on the three-dimensional structure of the ribosome, which he pursued using a wide variety of biophysical methods.

Inhaltsangabe

* Part 1. Fundamental Concepts.
* 1. On the Scattering of Electromagnetic Radiation by Atoms and
Molecules.
* 2. Molecular Scattering and the Fourier Transform.
* 3. Scattering by Condensed Phases: a More Sophisticated Look at
Atomic and Molecular Scattering.
* Appendix 3.3: Energy absorption and the imaginary part of ?.
* Part 2. Crystallography.
* 4. On the Diffraction of X-rays by Crystals.
* 5. On the Appearance of Crystalline Diffraction Patterns.
* 6. Solving the Phase Problem.
* 7. Electron Density Maps and Molecular Structures.
* Part 3. Non-Crystallographic Diffraction.
* 8. Diffraction from Non-Crystalline Samples.
* Part 4. Optical Microscopy.
* 9. Image Formation Using Lenses.
* 10. The Light Microscope.
* Part 5. Electron Microscopy.
* 11. Lenses that Focus Electrons.
* 12. Image Formation in the Electron Microscope.
* 13. Electron Microscopy in Three Dimensions.
* Appendix 13.1: Solving least squares problems.
* Appendix 13.2: Error propagation in linear systems.
* Appendix 13.3: The Fourier transform in cylindrical coordinates.