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Vitamin A is essential for various functions in the human body, including growth, epithelial differentiation, eyesight, immune system function, men's reproduction, and male infertility by enhancing sperm quality, bioenergetics, functioning, maintaining mitochondrial stability, and reducing oxidative damage. Males require dietary retinoid or vitamin A for spermatogenesis, as spermatogonial stem cells start the process through periodic RA after birth. Blood-testis barrier interactions and RA signals are crucial to the process of spermatogenesis.Spermatogenesis is a significant inducer of spermatogenesis in the mammalian testis. The undifferentiated spermatogonia are started by RA at the beginning of the 72-day spermatogenesis process in humans.