Volhard- Erdmann Cyclization
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Volhard-Erdmann cyclization is an organic synthesis of alkyl and aryl thiophenes by cyclization of disodium succinate or other 1,4-difunctional compounds ( -oxo acids, 1,4-diketones, chloroacetyl-substituted esters) with phosphorus heptasulfide.The reaction is named after Jacob Volhard and Hugo Erdmann.An example is the synthesis of 3-methylthiophene starting from itaconic acid

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Volhard-Erdmann cyclization is an organic synthesis of alkyl and aryl thiophenes by cyclization of disodium succinate or other 1,4-difunctional compounds ( -oxo acids, 1,4-diketones, chloroacetyl-substituted esters) with phosphorus heptasulfide.The reaction is named after Jacob Volhard and Hugo Erdmann.An example is the synthesis of 3-methylthiophene starting from itaconic acid