Voltage-gated Na+ channels as non-photonic sensor for reactive species - Ojha, Navin Kumar
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Reactive species (RS) play important roles in vital physiological processes. However, excessive RS damages cells and may contribute to the onset of several diseases. Therefore, there is a clear demand for sensitive probes that precisely monitor cellular RS with a high spatio-temporal resolution to understand the multifaceted role of RS in redox biology. Genetically encoded redox probes derived from green fluorescent protein (GFP), such as roGFP2 and Grx1-roGFP2, are promising tools for quantitative and dynamic observation of RS with spatio-temporal resolution. However, the excitation light…mehr

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Produktbeschreibung
Reactive species (RS) play important roles in vital physiological processes. However, excessive RS damages cells and may contribute to the onset of several diseases. Therefore, there is a clear demand for sensitive probes that precisely monitor cellular RS with a high spatio-temporal resolution to understand the multifaceted role of RS in redox biology. Genetically encoded redox probes derived from green fluorescent protein (GFP), such as roGFP2 and Grx1-roGFP2, are promising tools for quantitative and dynamic observation of RS with spatio-temporal resolution. However, the excitation light used to read-out the fluorescence of these proteins can lead to irreversible modification of cell constituents, which may result in either immediate or long-lasting alterations of molecular functions.
Autorenporträt
Dr. Navin Kumar Ojha, b. 1986, received his PhD in Biophysics in 2018 from the Medical Faculty of The Friedrich Schiller University of Jena, Germany. During his PhD, he studied the oxidative modification of voltage-gated sodium channels and was involved in the development of non-photonic and real-time redox sensors.