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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. This family represents the Kv1.4 voltage-gated potassium channel internal ribosome entry site (IRES). This region has been shown to mediate internal ribosome entry in cells derived from brain, heart, and skeletal muscle; tissues known to express Kv1.4 mRNA speciesVoltage-gated potassium channels are transmembrane channels specific for potassium and sensitive to voltage changes in the cell''s membrane potential. They play a crucial role during action potentials in returning the depolarized cell to a resting state.