Von Hippel Lindau Tumor Suppressor
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High Quality Content by WIKIPEDIA articles! The Von Hippel Lindau tumor suppressor protein is encoded by the VHL gene and when inactivated is associated with Von Hippel Lindau disease. Von Hippel Lindau syndrome (VHL) is a dominantly inherited hereditary cancer syndrome predisposing to a variety of malignant and benign tumors of the eye, brain, spinal cord, kidney, pancreas, and adrenal glands. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. Individuals with VHL syndrome inherit one mutation in the VHL protein that causes the protein's normal function to…mehr

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High Quality Content by WIKIPEDIA articles! The Von Hippel Lindau tumor suppressor protein is encoded by the VHL gene and when inactivated is associated with Von Hippel Lindau disease. Von Hippel Lindau syndrome (VHL) is a dominantly inherited hereditary cancer syndrome predisposing to a variety of malignant and benign tumors of the eye, brain, spinal cord, kidney, pancreas, and adrenal glands. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. Individuals with VHL syndrome inherit one mutation in the VHL protein that causes the protein's normal function to be lost or altered. Over time, sporadic mutation in the second copy of the VHL protein can lead to carcinomas.