High Quality Content by WIKIPEDIA articles! Wall is a town in Pennington County, South Dakota, United States. The population was 818 at the 2000 census. The town is most famous for Wall Drug Store, which opened as a small pharmacy during the Depression but eventually developed into a large roadside tourist attraction.According to the United States Census Bureau, the town has a total area of 2.1 square miles (5.3 km²), of which, 2.0 square miles (5.2 km²) of it is land and 0.04 square miles (0.1 km²) of it (1.94%) is water.