Water scarcity threaten national food security for millions of people, particularly in the arid and semi arid regions, more than 94% of Egypt area has an arid climate, where crop production needs supplemental irrigation. Limited surface water availability is a major constraint to increase grain production. Wheat is one of the most crops in Egypt and is cultivated in different agro-ecological regions of northern, southern and central parts of the country, under normal conditions, four to six irrigations are recommended for optimum wheat production in Egypt. Deficit irrigation has been practiced in the area with limited irrigation water resources; however it is important studying the limits of drought stress on the growth, yield and chemical content and physiological trait of wheat plant. The objectives of this study are to determine water requirement and study the effect of different water contents on growth, yield, its attributes, physiological, chemical and antioxidant enzymes responses to some wheat cultivars i.e. (Sakha 93 and Giza 168) under sandy soil conditions