High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! Wayne County is a county located in the U.S. state of Kentucky. As of 2000, the population was 19,923. Its county seat is Monticello. The county is named for Anthony Wayne. It is a prohibition or dry county. Wayne County was formed December 13, 1800 from Pulaski and Cumberland Counties. It was the 43rd county and is named for General "Mad Anthony" Wayne.