This book explores the role of bioinorganics in the regulation of key proteins and signaling pathways associated with cancer. Focusing on the p53 protein, it examines how metals, such as zinc and iron, influence its activity and function. The book discusses the mechanisms of p53 activation and regulation, how other tumor suppressor genes and signaling pathways interact with metals, and the impact of these interactions on tumor processes. It also presents potential applications of metal complexes and nanomaterials in modeling p53-metal interactions and developing new therapies. The conclusion highlights the promising prospects for more targeted and effective treatments in oncology thanks to bioinorganic research.