Mother-to-child transmission of HIV is the major source of HIV infection among children under the age of 15 years. Within the prevention programs, package of services including HIV counseling and testing, provision of prophylactic antiretroviral (ARV) drugs for mothers and babies, safe delivery practices and awareness creation of MTCT and PMTC of HIV are the main points. This study is thus to model women's knowledge on mother-to-child transmission of HIV during pregnancy in terms of some predictors. The data obtained from the 2011 EDHS with 15827 women in the age group 15-49 years. Binary logistic regression and descriptive statistical measures were applied. Women who attained higher education level have (81.3%) good knowledge about MTCT of HIV than women who educated secondary and less. The percent of knowing MTCT of HIV increase as education level increase. Among 33.2% of urban women, about 76.6% of them have knowledge about MTCT of HIV. According to the result of logistic regression, age, education level, religion, region, place of residence, frequency of reading newspaper, frequency of listening radio and HIV testing plays significance role in determining women's knowledge.