The general objective of this study was to assess the workplace health and safety practices and its effects on the employees of oil marketing companies (OMCs) in Ghana with specific reference to Ghana Oil Company Limited (GOIL). A stratified sampling technique was used to select the respondents and the data analysed using a statistical tool. The study revealed that staff and management are familiar with personal protective equipment (PPE). Also, effective implementation of workplace safety and health practices enhanced employee satisfaction and quality service delivery. It was further revealed that the major challenge facing GOIL in the implementation of workplace safety and health is the inability to severely punish culprits to deter others from flouting safety and health regulations. The study therefore recommended that management of GOIL should embark on intensive education of all practices relating to safety and health within the company and extend it to customers of the company. Regular and unannounced inspections by the regulating bodies of OMCs to help companies comply with health and safety standards should also be promoted.