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High Quality Content by WIKIPEDIA articles! X-linked agammaglobulinemia (also called X-linked hypogammaglobulinemia, XLA, Bruton type agammaglobulinemia, Bruton syndrome, or Sex-linked agammaglobulinemia) is a rare X-linked genetic disorder that discovered in 1952 which affects the body's ability to fight infection. XLA is an X-linked disorder, and therefore is more common in males. XLA patients do not generate mature B cells. B cells are part of the immune system and normally manufacture antibodies (called immunoglobulins) which defends the body from infections by sustaining an immunological humoral antibody response. Patients with untreated XLA are prone to develop serious and even fatal infections.