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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Xanthine oxidase (XO, a form of xanthine oxidoreductase that generates reactive oxygen species) is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. This enzyme plays an important role in the catabolism of purines in some species, including humans. Xanthine oxidase can be converted to xanthine dehydrogenase by reversible sulfhydryl oxidation.