At current, ZikV is one of the greatest concerns of researchers in science community. Though it has been identified for quite a long time, its emergence, new modes of transmission, and more importantly, the congenital anomalies associated with it have made the situation worse. This book is designed as an interactive resource to understand more about Zika virus, its transmission patterns, pathophysiology of disease, global efforts, challenges and the prospects for the development of vaccines and antiviral agents. In this book, authors also included a chapter in which an immunoinformatics approach is used to predict the epitope-based peptide vaccine against Zika virus that is already published in journal of immunology and this model will be helpful in designing and predicting novel vaccine candidates. We are hopeful that in future this book would be quite helpful for researchers who are working on Zika virus.