Zinc Finger Proteins is the first book to systematically assemble knowledge of various zinc finger proteins belonging to several families and to describe features of zinc finger proteins at levels ranging from atomic to cellular and to organismal. Significance of zinc itself is also addressed as are important domains often associated with zinc fingers. This book is an ideal resource for students who want to learn about zinc finger proteins as well as for scientists who work on gene expression, signal transduction, differentiation, development, cancer and neurological diseases.
Zinc Finger Proteins is the first book to systematically assemble knowledge of various zinc finger proteins belonging to several families and to describe features of zinc finger proteins at levels ranging from atomic to cellular and to organismal. Significance of zinc itself is also addressed as are important domains often associated with zinc fingers. This book is an ideal resource for students who want to learn about zinc finger proteins as well as for scientists who work on gene expression, signal transduction, differentiation, development, cancer and neurological diseases.
Shiro Iuchi, Harvard Medical School, Boston, MA, USA / Natalie Kuldell, Massachusetts Institute, Cambridge, MA, USA
Inhaltsangabe
From the contents: Applications in Gene Regulation.- C2H2 Zinc Fingers As DNA Binding Domains.- TFIIIA GAGA- DNA Interaction.- The DNA-Binding Domain of GATA Transcription Factors A Prototypical Type IV Cys2-Cys2 Zinc Finger.- MutM: Single C2C2 Zinc Finger-DNA Interaction.- Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function -Zinc Finger Interactions with Metals and Other Small Molecules.- Synthetic Zinc Finger Transcription Factors.- TFIIIA and p43: Binding to 5S Ribosomal RNA.- RNA Binding by Single Zinc Fingers.- Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA.- Tandem CCCH Zinc Finger Proteins in mRNA Binding 80- Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a.- LIM Domain and Its Binding to Target Proteins.- RING Finger-B Box-Coiled Coil (RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation.- Structure and Function of the CBP/p300 TAZ Domains.- A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2.
From the contents: Applications in Gene Regulation.- C2H2 Zinc Fingers As DNA Binding Domains.- TFIIIA GAGA- DNA Interaction.- The DNA-Binding Domain of GATA Transcription Factors A Prototypical Type IV Cys2-Cys2 Zinc Finger.- MutM: Single C2C2 Zinc Finger-DNA Interaction.- Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function -Zinc Finger Interactions with Metals and Other Small Molecules.- Synthetic Zinc Finger Transcription Factors.- TFIIIA and p43: Binding to 5S Ribosomal RNA.- RNA Binding by Single Zinc Fingers.- Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA.- Tandem CCCH Zinc Finger Proteins in mRNA Binding 80- Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a.- LIM Domain and Its Binding to Target Proteins.- RING Finger-B Box-Coiled Coil (RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation.- Structure and Function of the CBP/p300 TAZ Domains.- A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2.
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