Just as the world's oceans were about to be opened by Columbus's epochal voyage, the treaty sought to limit the seas to these two favoured Catholic nations. The edict was to have a profound influence on world history: it propelled Spain and Portugal to superpower status, steered many other European nations on a collision course and became the central grievance in two centuries of international espionage, piracy and warfare.
At the heart of one of the greatest international diplomatic and political agreements of the last five centuries were the strained relationships and passions of a handful of powerful individuals. They were linked by a shared history, mutual animosity and personal obligations.
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