25 Years of p53 Research (eBook, PDF)

Redaktion: Hainaut, Pierre; Wiman, Klas G.

• Format: PDF

Produktbeschreibung

p53 has emerged as a key tumor suppressor and important target for novel cancer therapy. This book, written by world-leading p53 researchers including many of those who have shaped the field over the past 25 years, provides unique insights into the progress of the field and the prospects for better cancer diagnosis and therapy in the future.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 446
• Erscheinungstermin: 5. Oktober 2007
• Englisch
• ISBN-13: 9781402029226
• Artikelnr.: 37342922

Inhaltsangabe

The First Twenty-Five Years of p53 Research.- Regulation of p53 DNA Binding.- 20 Years of DNA Damage Signaling to p53.- Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX.- Regulation of the p53 Response by Cellular Growth and Survival Factors.- P53, Cell Cycle Arrest and Apoptosis.- P53 Has a Direct Pro-apoptotic Action at the Mitochondria.- Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor.- P53, P63, and P73: Internecine Relations?.- P73, P63 and Mutant P53: Members of Protein Complexs Floating in Cancer Cells.- P53: Gatekeeper, Caretaker or Both?.- Analysis of p53 Gene Alterations in Cancer: A Critical View.- Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection.- Prognostic and Predictive Value of TP53 Mutations in Human Cancer.- P53 Links Tumor Development to Cancer Therapy.- Novel p53-Based Therapies: Strategies and Future Prospects.- Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue.- Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy.- Novel Approaches to p53-Based Therapy: ONYX-015.- p53 as Seen by an Outsider.