Megan M. Reynolds, Louis Theodore

A Guide to Virology for Engineers and Applied Scientists (eBook, ePUB)

Epidemiology, Emergency Management, and Optimization

• Format: ePub

Produktbeschreibung

A Guide to Virology for Engineers and Applied Scientists A hands-on guide covering the fundamentals of virology written from an engineering perspective In A Guide to Virology for Engineers and Applied Scientists: Epidemiology, Emergency Management, and Optimization, a team of distinguished researchers delivers a robust and accessible treatment of virology from an engineering perspective. The book synthesizes a great deal of general information on viruses--including coronaviruses--in a single volume. It provides critical context that engineers and applied scientists can use to evaluate and manage viruses encountered in the environment. The fundamental principles of virology are explored with calculation details for health and hazard risk assessments. Each chapter combines numerous illustrative examples and sample problems ideal for advanced courses in environmental health and safety, pharmaceuticals, and environmental science and engineering. Readers will also find: * A detailed introduction to health and hazard risk analysis and assessment that is complete with technical information and calculation details * Comprehensive illustrative examples and practice problems for use by educators and professionals in training * Practical discussions of virology by authors with combined experience in pharmaceuticals and environmental health and safety * Thorough treatments of virology from the perspective of a professional engineer * A definitive source for those working in related fields who wish to deepen their overall understanding of viruses Perfect for chemical, civil, mechanical, biochemical engineers, and applied scientists, A Guide to Virology for Engineers and Applied Scientists: Epidemiology, Emergency Management, and Optimization will also earn a place in the libraries of industrial hygiene professionals and instructors, students, and practitioners in environmental health, pharmaceuticals, public health, and epidemiology.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 416
• Erscheinungstermin: 12. Januar 2023
• Englisch
• ISBN-13: 9781119853152
• Artikelnr.: 67320689

Autorenporträt

Megan M. Reynolds, BSChE, MS, MBA, is a freelance medical writer and editor with a focus on infectious diseases. She holds degrees in chemical engineering, international business, and medicine, and has more than 12 years' experience in the pharmaceutical industry in a variety of capacities. Louis Theodore, MChE, EngScD, is a retired professor of chemical engineering with over 50 years' education experience. He has authored numerous publications and has served as section editor to the last four editions of Perry's Chemical Engineer's Handbook. Dr. Theodore currently works as an environmental engineering consultant.

Inhaltsangabe

Preface xvii

About the Authors xix

Part I Introduction to Viruses 1

1 Overview of Molecular Biology 3
Contributing Author: Sarah Forster

1.1 Cell Basics 4

1.1.1 Cytoplasm 5

1.1.2 Ribosomes 5

1.1.3 Nucleus 6

1.2 Cell Replication 6

1.2.1 Nucleic Acids 6

1.2.2 DNA Replication 7

1.2.3 RNA Structure and Role 9

1.2.4 Protein Synthesis 9

1.3 Cellular Transport 11

1.3.1 Plasma Membrane 11

1.3.2 Cell Signaling 11

1.4 Immune Defense 12

1.4.1 Innate Immunity 12

1.4.2 Adaptive Immunity 13

1.4.2.1 Humoral Immunity 13

1.4.2.2 Cellular Immunity 14

1.5 Applications 14

1.6 Chapter Summary 16

1.7 Problems 16

References 16

2 Basics of Virology 19

2.1 Viral Basics and Terminology 19

2.2 Viral Life Cycle 21

2.2.1 Attachment (Connection) 21

2.2.2 Penetration (Entry) 22

2.2.3 Uncoating 22

2.2.4 Replication 23

2.2.5 Assembly 23

2.2.6 Maturation and Release 23

2.3 Virus Structure and Classification 24

2.3.1 DNA Viruses 25

2.3.2 RNA Viruses 25

2.3.3 Reverse Transcription Viruses (Retroviruses) 27

2.4 Viruses in Context of the Tree of Life 27

2.5 Viral Genetics 28

2.5.1 Antigenic Shift 28

2.5.2 Antigenic Drift 29

2.5.3 Phenotypic Mixing 29

2.5.4 Complementation 29

2.6 Applications 29

2.7 Chapter Summary 31

2.8 Problems 31

References 32

3 Pandemics, Epidemics, and Outbreaks 33

3.1 Human Viral Diseases 34

3.2 Ebola and Marburg Viruses 35

3.2.1 Symptoms 36

3.2.2 Diagnosis 37

3.2.3 Prevention and Treatment 37

3.3 Human Immunodeficiency Disease (HIV) 38

3.3.1 HIV Symptoms 39

3.3.1.1 Stage 1: Acute Infection 39

3.3.1.2 Stage 2: Chronic HIV Infection (Latent Phase) 39

3.3.1.3 Stage 3: Acquired Immunodeficiency Syndrome (AIDS) 39

3.3.2 Diagnosis 40

3.3.3 HIV Prevention and Treatment 40

3.4 Influenza 41

3.4.1 Influenza Symptoms 41

3.4.2 Influenza Diagnosis 42

3.4.3 Influenza Prevention and Treatment 42

3.4.4 Influenza Pandemics 43

3.5 Coronaviruses 44

3.5.1 Symptoms 45

3.5.1.1 Typical Acute Symptoms 45

3.5.1.2 Post-COVID Conditions 46

3.5.1.3 COVID-19 Multiorgan System Effects (MIS) 46

3.5.2 COVID-19 Diagnosis 47

3.5.3 COVID-19 Prevention and treatment 48

3.6 Current and Emerging Viral Threats 48

3.7 Applications 51

3.8 Chapter Summary 52

3.9 Problems 53

References 53

4 Virus Prevention, Diagnosis, and Treatment 57

4.1 Vaccination Successes and Challenges 58

4.2 Current Vaccine Technology 59

4.2.1 Live-attenuated vaccines 60

4.2.2 Inactivated vaccines 61

4.2.3 Recombinant Subunit Vaccines 61

4.2.4 Viral Vector Vaccines 62

4.2.5 Messenger RNA (mRNA) Vaccines 62

4.3 U.S.-Approved Vaccines and Requirements 63

4.3.1 Commercially Available Viral Vaccines 63

4.3.2 Vaccination Requirements 63

4.4 Viral Testing and Diagnosis 64

4.4.1 Viral Testing 65

4.4.2 Antibody Testing 66

4.5 Antiviral Treatment Options 66

4.5.1 HIV 67

4.5.1.1 Nucleoside Reverse Transcriptase Inhib