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This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer. Furthermore it: Details information about the structure and function of the ZP domain in ZPDC-proteins | Provides illustrations of the organization of ZPDC-proteins, the genes that encode the proteins, and examples of mutations in the ZP domain that cause diseases | Speculates as to the evolution of the ZP domain and potential therapeutics for…mehr
This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer. Furthermore it:
Details information about the structure and function of the ZP domain in ZPDC-proteins
Provides illustrations of the organization of ZPDC-proteins, the genes that encode the proteins, and examples of mutations in the ZP domain that cause diseases
Speculates as to the evolution of the ZP domain and potential therapeutics for diseases stemming from ZP domain mutations
Eveline S. Litscher, Ph.D., is Assistant Professor in the Department of Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. Previously a Swiss National Science Foundation post-doctoral fellow in the Department of Cell and Developmental Biology at the Roche Institute of Molecular Biology, she has more than 20 years of research experience working on extracellular coat proteins of mammalian and non-mammalian eggs, and has published more than 45 primary papers and reviews.
Paul M. Wassarman, Ph.D., is Professor in the Department of Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. Previously a faculty member in the Department of Biological Chemistry at Harvard Medical School and in the Department of Cell and Developmental Biology at the Roche Institute of Molecular Biology, he has more than 35 years of research experience working on extracellular coat proteins of mammalian and non-mammalian eggs, and has published more than 220 primary papers and reviews.
Inhaltsangabe
List of Tables xi
Introduction to the Wiley Series on Protein and Peptide Science xiii
Preface xv
Acknowledgments xvii
List of Abbreviations xix
Part A Zona Pellucida Domain Proteins 1
A.1 Nature of the Zona Pellucida Domain 1
A.2 Mouse ZP Proteins 2
A.3 Synthesis, Secretion, and Assembly of ZP Proteins 7
A.4 Structure of the ZPD 13
A.5 Evolution of ZPD Proteins 18
Part B Mammalian Zona Pellucida Proteins 21
B.1 Introduction 21
B.2 Monotremes 22
B.3 Marsupials 24
B.4 Placental Mammals 25
B.4.a Mouse 26
B.4.b Rat 26
B.4.c Hamster 28
B.4.d Rabbit 30
B.4.e Cow 32
B.4.f Pig 33
B.4.g Dog 35
B.4.h Monkey 36
B.4.i Chimpanzee 38
B.4.j Human 40
B.5 Mammalian ZP Proteins as Antifertility Vaccines 45
B.6 Summary Tables 48
Part C Mammalian Zona Pellucida Domain Proteins 53
C.1 Betaglycan/TGFβ?]Receptor Type III 53
C.2 CUB and Zona Pellucida?]like Domain 1 (CUZD?]1) Proteins 55
C.2.a UTCZP/Itmap-1 55
C.2.b UO-44/ERG-1 56
C.3 Deleted in Malignant Brain Tumor 1 (DMBT1) Proteins 58
C.3.a CRP-Ductin 58
C.3.b DMBT1 60
C.3.c Ebnerin 62
C.3.d Hensin 63
C.3.e Vomeroglandin 65
C.4 Endoglin/CD?]105 66
C.5 Liver?]Specific ZPD?]Containing Protein (LZP) 68
C.6 Oocyte?]Secreted Protein 1 (Oosp1) 69
C.7 Pancreatic Zymogen Granule Protein (GP?]2) 70
C.8 Placenta?]Specific 1 (Plac1) 71
C.9 Tectorin?]α and ?]β 72
C.10 Uromodulin/Tamm–Horsfall Protein 78
C.11 Uromodulin?]like Proteins 81
C.12 Summary Tables 84
Part D Non?]mammalian Zona Pellucida Domain Proteins 87
