Acetaminophen Toxicity (eBook, ePUB)

Experimental and Clinical Advances
Redaktion: Rumack, Barry; McGill, Mitchell; Jaeschke, Hartmut

• Format: ePub

Produktbeschreibung

Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity. Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity. - Includes comprehensive coverage of fundamental mechanisms of toxicity. - Provides risk analysis regardless of patient presentation or timing of ingestion or amount with algorithmic support. - Covers how to determine the level of toxicity and need for liver transplant with algorithmic support. - Outlines new therapeutic approaches.

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 400
• Erscheinungstermin: 21. November 2024
• Englisch
• ISBN-13: 9780443158780
• Artikelnr.: 72263459

Inhaltsangabe

PART I: Foundational Aspects 1. History of Acetaminophen 2. Intracellular
Signaling Mechanisms of Cell Death. 3. Hepatic MAP kinase signaling
pathways in APAP-induced cell death 4. Adaptive Mechanisms modulating
APAP-induced Cell Death 5. Mode of Cell Death 6. Inflammation 7. Hepatic
Regeneration 8. Translation of Acetaminophen Hepatotoxicity Mechanisms from
Models to Humans 9. Renal Toxicity 10. Genomics, Proteomics and
Metabolomics Part II: Clinical and Therapeutic 11. Pharmacokinetics and
pharmacodynamics - the absorption, distribution, metabolism and excretion
of acetaminophen orally and intravenously 12. Minimally Invasive Clinical
Biomarkers for use in Acetaminophen Hepatotoxicity 13. Adducts 14. The
Rumack-Matthew Nomogram: Development, evolution, and use 15.
Pathophysiology of Acetaminophen Overdose 16. Kings College Criteria and
Liver Transplantation 17. Sustained-Release Acetaminophen 18.
Acetaminophen, Ethanol and other Co-Ingestions 19. N-Acetylcysteine (NAC)
20. Fomepizole 21. Pre-Hospital, Poison Center and Initial Hospital Care of
Overdose and Potential Overdosed Patients 22. Epidemiology NPDS (Poison
Center Data) CDC and Other Databases 23. Acetaminophen safety in chronic
liver diseases