Karsten Schrör

Acetylsalicylic Acid (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Written by a leading expert on Aspirin-related research, this is the most comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever.

The text is written with a wide audience in mind and to be readily understandable for clinicians, pharmacists, biomedical researchers and pharmacologists alike.

This third completely revised edition contains the latest results of clinical and pharmacological research on Acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention and treatment of cardiovascular diseases, thromboinflammation and colorectal cancer.

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Produktdetails

• Verlag: De Gruyter
• Seitenzahl: 642
• Erscheinungstermin: 18. Juli 2022
• Englisch
• ISBN-13: 9783110746488
• Artikelnr.: 64300530

Autorenporträt

Karsten Schrör, MD.

is professor of Pharmacology and retired Chairman of the Department of Pharmacology and Clinical Pharmacology at the Heinrich-Heine-University in Düsseldorf (Germany). He carried out postdoctoral studies at the universities of Halle, Mainz, Köln (Germany) and the Wellcome Research Laboratories in Beckenham (UK) under the supervision of the later Nobel laureate Sir John Vane. Karsten Schrör held several guest professorships in the USA and was President of the German Society for Pharmacology (2005-2010). He is member of the German National Academy of Sciences (Leopoldina) and Schmiedeberg-Medal Awardee. Karsten Schrör has published extensively in the area of aspirin and prostaglandin research with focus on platelet function, myocardial ischemia and the clotting system.

Inhaltsangabe

TABLE OF CONTENTS1. GENERAL ASPECTS1.1 HISTORY1.1.1 WILLOW BARK AND LEAVES AS ANTIPYRETIC, ANTI-INFLAMMATORY ANALGESICS1.1.2 SALICYLATES AS THE ACTIVE INGREDIENT OF WILLOW BARK AND OTHER NATURAL SOURCES1.1.3 SYNTHESIS OF ACETYLSALICYLIC ACID AND FIRST CLINICAL STUDIES1.1.4 MODE OF ASPIRIN ACTION1.1.5 ANTI-INFLAMMATORY/ANALGESIC ACTIONS OF ASPIRIN1.1.6 ASPIRIN IN THE CARDIOVASCULAR SYSTEM1.1.7 CURRENT RESEARCH TOPICS1.2 CHEMISTRY1.2.1 STRUCTURES AND CHEMICAL PROPERTIES OF SALICYLATES1.2.2 DETERMINATION OF SALICYLATES2. PHARMACOLOGY2.1 PHARMACOKINETICS2.1.1 ABSORPTION AND DISTRIBUTION2.1.2 BIOTRANSFORMATION AND EXCRETION2.2 CELLULAR MODES OF ACTION2.2.1 INHIBITION OF CYCLOOXYGENASES2.2.2 COX-INDEPENDENT ACTIONS ON CELL FUNCTION2.2.3 ENERGY METABOLISM2.3 ACTIONS ON ORGANS AND TISSUES2.3.1 HEMOSTASIS AND THROMBOSIS2.3.2 INFLAMMATION, PAIN AND FEVER2.3.3 ASPIRIN AND MALIGNANCIES3. TOXICITY AND DRUG SAFETY3.1 SYSTEMIC SIDE-EFFECTS3.1.1 ACUTE AND CHRONIC TOXICITY3.1.2 BLEEDING DISORDERS3.1.3 SAFETY PHARMACOLOGY IN PARTICULAR LIFE SITUATIONS3.2 ORGAN TOXICITY3.2.1 GASTROINTESTINAL (GI) TRACT3.2.2 KIDNEY3.2.3 LIVER3.2.4 AUDIOVESTIBULAR SYSTEM3.3 NON-DOSE-RELATED (PSEUDO)ALLERGIC ACTIONS OF ASPIRIN3.3.1 ASPIRIN HYPERSENSITIVITY (WIDAL'S SYNDROME)3.3.2 URTICARIA/ANGIOEDEMA, STEVENS-JOHNSON- AND LYELL-SYNDROME3.3.3 REYE SYNDROME4. CLINICAL APPLICATIONS OF ASPIRIN4.1 THROMBOEMBOLIC DISEASES4.1.1 CORONARY VASCULAR DISEASE4.1.2 CEREBROVASCULAR DISEASES4.1.3 PERIPHERAL ARTERIAL DISEASE (PAD)4.1.4 VENOUS THROMBOSIS4.1.5 PREECLAMPSIA4.1.6 ASPIRIN "RESISTANCE"4.2 PAIN, FEVER AND INFLAMMATORY DISEASES4.2.1 ASPIRIN AS AN ANTIPYRETIC ANALGESIC4.2.2 ARTHRITIS AND RHEUMATISM4.2.3 KAWASAKI DISEASE4.3 FURTHER CLINICAL INDICATIONS4.3.1 COLORECTAL CANCER4.3.2 ALZHEIMER DISEASEABBREVIATIONS (NO ACRONYMS FOR CLINICAL STUDIES)ACRONYMS FOR CLINICAL STUDIESINDEX TERMS (PRELIMINARY)