Chang-Hwei Chen

Activation and Detoxification Enzymes (eBook, PDF)

Functions and Implications

• Format: PDF

Produktbeschreibung

There are many advances that have been made in the past decades towards the understanding of functions and implications of activation enzymes and detoxification enzymes. An organized, concise overview is needed for the readers who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology and chemistry. This book is intended to serve this purpose as an introduction to the subject. Furthermore, major topics in the book, excluding catalytic reactions and structural properties, may have interest to other readers who have knowledge of basic sciences and understanding enzyme related information. The book discusses subjects associated with foreign compound metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, phase I and phase II enzymes, catalytic properties, reactive intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary related enzyme modulators, and structural characteristics of enzyme inducers.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 182
• Erscheinungstermin: 16. November 2011
• Englisch
• ISBN-13: 9781461410492
• Artikelnr.: 37348536

Autorenporträt

Chang-Hwei Chen, PhD, is a biophysicist at the Institute of Health and the Environment, Professor Emeritus of Department of Biomedical Sciences at the School of Public Health, and Former Adjunct Professor of Physics at the University of Albany, Albany, New York 

Inhaltsangabe

Overview.- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles.- Transport and Excretion of Foreign Compounds.- Metabolic Conversion of Foreign Compounds.- Phase I Activation Enzymes.- Phase II Detoxification Enzymes.- Catalytic Reactions of Activation Enzymes.- Catalytic Reactions of Detoxification Enzymes.- Reactive Intermediates and their Interactions.- Metabolite - Associated Cell Toxicities.- Oxidative Stress and Electrophilic Stress.- Metabolic Enzymes: Polymorphism and Species Differences.- Defense Against Oxidative Stress: Nrf2-ARE Pathway.- Inducibility of Metabolic Enzymes.- Inducers of Metabolic Enzymes.- Diversified Classes of Enzyme Modulators.- Metabolite - Mediated Disease Conditions.- Metabolic Enzyme Induction for Health Benefits.- Diet Effects on Metabolic Enzymes.

Rezensionen

"This book succeeds in delivering a broad overview of the subject with a bias towards food components and the consequences of anutrient intake - certainly an interesting aspect. ... this is satisfactory for those just embarking on a career into the fascinating but complex world of drug and foreign compound metabolism." (Steve Mitchell, International Society for the Study of Xenobiotics-Newsletter, January, 2013)