ADME Processes in Pharmaceutical Sciences (eBook, PDF)

Dosage, Design, and Pharmacotherapy
Redaktion: Talevi, Alan; Quiroga, Pablo A.

• Format: PDF

Produktbeschreibung

The Second Edition of the ADME Processes in Pharmaceutical Sciences maintains the general structure of the first volume. The first part is dedicated to the generalities of LADME processes, including compartmental pharmacokinetics, and the second part is dedicated to burgeoning topics in the field, including pharmaceutical nanocarriers, pharmacogenomics, and pharmacokinetics of biologicals.

The contents of the first edition have been kept (revised, updated and expanded) and six entirely new chapters are introduced to this second edition. American, European, and Latin American experts from both industry and academia converge in this volume intended for undergraduate and graduate Pharmacy, Medicine, and other health care careers, but also for professionals from other related fields working in relation to pharmaceuticals, such as chemists, biochemists, material scientists, bioengineers and molecular biologists.

The volume is abundant in pedagogical features, including highlights, definitions, figures, tables, book recommendations, case studies and questions. ADME Processes (2nd Edition) is designed as a core textbook for pharmacology, pharmacokinetics, biopharmacy, drug design, medicinal chemistry, and pharmaceutical technology courses.

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Produktdetails

• Verlag: Springer Nature Switzerland
• Seitenzahl: 493
• Erscheinungstermin: 27. März 2024
• Englisch
• ISBN-13: 9783031504198
• Artikelnr.: 70256166

Autorenporträt

Prof. Alan Talevi obtained his Pharmacy degree in 2004 and completed his PhD studies in 2007, both at the University of La Plata. He obtained the award for the best PhD thesis from the Argentinean Chemical Society (2008) and the Award to Scientific Production from the National University of La Plata (2016). He holds a permanent position at the Argentinean National Council of Scientific and Technical Research since 2010, and he is Full Professor of the Biopharmacy course at the Faculty of Exact Sciences, University of La Plata. He has published over 100 articles in periodicals and more than 50 book chapters and entries, mostly in the fields of drug discovery and pharmacokinetics. He was elected Head of the Department of Biological Sciences of the Faculty of Exact Sciences, University of La Plata, between 2015 and 2017. In 2018 he became the Head of the Laboratory of Bioactive Compound Research and Development (LIDeB, University of La Plata). External reviewer for several agencies and universities, including Argentinean National Agency of Scientific and Technical Promotion, the United Nations University, the National Science Center (Poland), KU Leuven (Belgium), CONCYTEC (Perú), UK Research and Innovation (UK). Argentinean Ministry of National Education, University of La República (Uruguay), National Agency of Scientific and Technical Promotion (Uruguay). Reviewer of more than 80 periodicals, including Nature Communications, Scientific Reports, Journal of Medicinal Chemistry, Journal of Chemical Information and Modelling, Journal of Molecular Graphics and Modelling, PLoS One, Expert Opinion on Drug Delivery, Expert Opinion on Drug Discovery, Expert Opinion on Drug Metabolism and Toxicology, European Journal of Medicinal Chemistry, European Journal of Pharmacology, International Journal of Pharmaceutics. Member of the editorial board of Current Therapeutic Research (2023 and continues) and the Latin American Journal of Pharmacy (2014 and continues). Associateeditor for Frontiers in Natural Products (2023 and continues). Reviewing editor for eLife (2022 and continues). Guest editor of Mini-Reviews in Medicinal Chemistry, Current Drug Safety, and Frontiers in Chemistry. Editor of the ADME Encyclopedia (Major Reference Works, Springer Nature, 2022), Antiepileptic Drug Discovery Novel Approaches volume (Springer Protocols series, 2016) and Biopharmaceutical processes (University of La Plata Publishing, 2016), among others. He has taught several PhD courses and postgraduate courses in Argentina, Uruguay, Mexico, Ecuador and Perú, and he has acted as invited lecturer at Universidad Autonoma de México, Universidad de Guadalajara (México) and Universidad de Salamanca (Spain), among others. Pablo Quiroga is a Pharmacist and has Bachelor in Pharmaceutical Sciences from the Faculty of Exact Sciences of the University of La Plata (UNLP). University Expert in Toxicology and Master of Science in Toxicology of the University of Seville, Spain. He is a Full Professor of the Chairs of Quality Control of Drugs and Pharmaceutical Toxicology of the Faculty of Exact Sciences of the UNLP. Chief of Pharmacological Research Department - Laboratorios Bagó S.A. Member of the Council of Experts of Argentinean Pharmacopoeia. Co- Editor of The E-Books: Pharmaceutical Analysis (2013), and Biopharmaceutical Processes (2016)- University of La Plata Publishing - EDULP. Co-author  of several scientific publications. External reviewer of the UBACYT 2014-2017 Research Projects-UBA (University of Buenos Aires). Member of American Association of Pharmaceutical Scientists (AAPS) and the Argentinean Association of Industrial Pharmacy and  Biochemistry (SAFYBI). Workshop Co-Chairs and Speaker  "Implementation of Biowaivers based on the Biopharmaceutics Classification System"- held by the Focus Group on Biopharmaceuticals Classification System (BCS) and Biowaivers -International Pharmaceutical Federation (FIP) and Faculty of ExactSciences - UNLP. Workshop Member of the Organizing Committee of  "Dissolution Testing and Bioequivalence"   held by American Association of Pharmaceutical Scientists (AAPS) and Faculty of Exact Sciences - UNLP. He is a member of the Argentinean National Academy of Pharmacy and Biochemistry.

Inhaltsangabe

Part 1: The basics of ADME processes.- Chapter 1-Introduction. Biopharmaceutics and Pharmacokinetics.- Chapter 2-Drug release.- Chapter 3-Drug Absorption.- Chapter 4-Drug Distribution.- Chapter 5-Drug Metabolism.- Chapter 6-Drug Excretion.- Chapter 7-Drug Delivery Routes.- Chapter 8-Compartmental Pharmacokinetic Models.- Chapter 9-Regulatory Requirements and Applications of Physiologically Based Pharmacokinetic Models.- Chapter 10-Drug Drug and Food Drug Interactions of Pharmacokinetic Nature.- Part 2: Specialized topics.- Chapter 11-Nanocarriers: Delivery Routes.- Chapter 12-Advanced Techniques for Quality Assessment of Nanocarriers.- Chapter 13-Nanomedicines Obtained by Nanoprinting.- Chapter 14-Absorption, Distribution, Metabolism and Excretion of Biopharmaceutical Drug Products.- Chapter 15-In silico and in vitro ADME predictions.- Chapter 16-Relationship Between Pharmacokinetics and Pharmacogenomics and Its Impact on Drug Choice and Dose Regimens.- Chapter 17-The Relationship Between Pharmacogenomics and Pharmacokinetics and Its Impact on Drug Choice and Dosing Regimens in Pediatrics.- Chapter 18-Bioavailability and Bioequivalence studies.- Chapter 19-Drug transporters - Physiological role and Their Impact on Pharmacotherapy.- Chapter 20-Blood Flow Distribution and Membrane Transporters As Determinant Factors Of Tissue Drug Concentration.