Advances in Immunology (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Advances in Immunology, Volume 156, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering self-referential immune recognition through C-type lectin receptors, genetic susceptibility to autoimmunity, activation and regulation of the cGAS-STING pathway and the implications of IL-15 trans-presentation on the immune response.

• Presents current developments and comprehensive reviews in immunology
• Provides the latest in a longstanding and respected serial on the subject matter
• Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of regulatory T-cells in infection and Factor H and Properdin and their regulation

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 140
• Erscheinungstermin: 19. November 2022
• Englisch
• ISBN-13: 9780323989480
• Artikelnr.: 66458283

Autorenporträt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work i

n Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Kenneth M. Murphy works in Washington University School of Medecine, USA.

Inhaltsangabe

1. Self-referential immune recognition through C-type lectin receptors



Carla Guenther, Masamichi Nagae and Sho Yamasaki



2. Genetic susceptibility to autoimmunity: Current status and challenges



Miaozhen Huang and Huji Xu



3. Recent advances in the activation and regulation of the cGAS-STING pathway



Run Fang, Qifei Jiang, Xiaoyu Yu, Zhen Zhao and Zhengfan Jiang



4. The implications of IL-15 trans-presentation on the immune response



Thomas A. Waldmann, Robert Waldmann, Jian-Xin Lin and Warren J. Leonard