Advances in Nucleic Acid Therapeutics (eBook, PDF)

Redaktion: Agrawal, Sudhir; Gait, Michael J

• Format: PDF

Produktbeschreibung

The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.

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Produktdetails

• Verlag: Royal Society of Chemistry
• Seitenzahl: 541
• Erscheinungstermin: 8. Februar 2019
• Englisch
• ISBN-13: 9781788015714
• Artikelnr.: 55443499

Inhaltsangabe

History and Development of Nucleotide Analogues in Nucleic Acids Drugs
Mechanisms of Antisense Oligonucleotides
The Medicinal Chemistry of RNase H-activating Antisense Oligonucleotides
Antisense Technology: Liver Targeting and Beyond for Drug Discovery
Oligonucleotide-based Toll-like Receptor Antagonists and Therapeutic Applications
Splicing Modulation for Therapeutics
Targeting Toxic Repeats
Research and Development of Oligonucleotides Targeting MicroRNAs (miRNAs)
Oligonucleotide Targeting of Long Non-coding RNAs
Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics-Pharmacodynamics Relationships of Medicinal Oligonucleotides
Liver-targeted RNAi Therapeutics: Principles and Applications
Advances and Challenges of RNAi-Based Anti-HIV Therapeutics
Nucleic Acid Innate Immune Receptors
Synthetic Agonists of Toll-like Receptors and Therapeutic Applications
Prostate-specific Membrane Antigen (PSMA) Aptamers for Prostate Cancer Imaging and Therapy
Aptamers and Clinical Applications
CRISPR-based Technologies for Genome Engineering: Properties, Current Improvements and Applications in Medicine
Therapeutic Potential of Ribozymes
Large-scale Automated Synthesis of Therapeutic Oligonucleotides: A Status Update
Preclinical and Clinical Drug-metabolism, Pharmacokinetics and Safety of Therapeutic Oligonucleotides
Subject Index