Advances in Prodrugs (eBook, ePUB)

Design and Therapeutic Applications
Redaktion: Trandafir Supuran, Claudiu; Tanini, Damiano; Angeli, Andrea

• Format: ePub

Produktbeschreibung

Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases. - Highlights chemistry and pharmacology-related aspects, offering a versatile tool for readers involved in prodrug development and study - Discusses in-depth treatment of several activation mechanisms and applications for disease treatments - Covers a range of topics from basic contents, design, and mechanisms of actions to current applications in drugs

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 350
• Erscheinungstermin: 1. Oktober 2024
• Englisch
• ISBN-13: 9780443156342
• Artikelnr.: 72251444

Inhaltsangabe

PART I: INTRODUCTION
1. PRODRUGS: GENERAL CONCEPTS, PRODRUG DESIGN IN MEDICINAL CHEMISTRY
Andrea Angeli, Claudiu T. Supuran and Damiano Tanini
PART II: ACTIVATION MECHANISMS AND RELATED FUNCTIONAL GROUPS
2. pH-SENSITIVE PRODRUGS
Emanuela Berrino
3. ENZYME-MEDIATED ACTIVATION OF PRODRUGS
Simone Carradori, Ilaria D'Agostino and Concettina La Motta
4. REACTIVE OXYGEN SPECIES-RESPONSIVE PRODRUGS
Jean-Yves Winum
5. PHOTOACTIVABLE PRODRUGS
Damiano Tanini
6. ANTIBODY DIRECTED ENZYME PRODRUG THERAPY (ADEPT)
Paolo Rovero, Andrea Di Santo and Anna Maria Papini
7. SELF-ASSEMBLING PRODRUGS
Mariana Pinteala V
8. PRODRUG-BASED NANOMEDICINES: A SUCCESSFUL RATIONALE TO DESIGN NOVEL AND
EFFECTIVE DELIVERY STRATEGIES
Giulia Vanti
9. HYPOXIA-ACTIVATED PRODRUGS
Wagdy M. Eldehna
PART III: APPLICATION OF PRODRUGS IN THE TREATMENT OF DISEASES
10. ANTIVIRAL AND ANTIRETROVIRAL PRODRUGS
Claudiu T. Supuran and Luigi Pisano
11. PRODRUGS FOR CANCER THERAPY
Andrea Angeli
12. PRODRUGS FOR NEURODEGENERATIVE DISEASES
Paolo Guglielmi, Arianna Granese, Daniela Secci and Paola Chimenti
13. PRODRUGS IN CARDIOVASCULAR THERAPY
Laura Fumagalli and Angelica Artasensi
14. PRODRUGS FOR OCULAR DISEASES
Alessio Nocentini
15. ANTIBACTERIAL PRODRUGS
Raivis alubovskis
16. PRODRUGS AGAINST NEGLECTED DISEASES
ALANE BEATRIZ VERMELHO