Advances in Tumor Immunology and Immunotherapy (eBook, PDF)

Redaktion: Rosenblatt, Joseph D.; Ochoa, Augusto; Barber, Glen N.; Podack, Eckhard R.

• Format: PDF

Produktbeschreibung

This volume explores recent advances in understanding of fundamental immunology and insights into the dynamic interactions between tumors and the immune system, that provide new opportunities for therapeutic intervention in cancer. Chapter topics include evolving paradigms in the innate and adaptive response, newly appreciated immunosuppressive mechanisms, and novel preclinical strategies for manipulation of the immune system for therapeutic benefit in cancer. In addition, recent successes in the clinic, and emerging opportunities are covered. Future possibilities, such as the use of antibody engineering, fusion proteins, and the retargeting of immune cells through T-cell receptor engineering are discussed by leaders in the field, focusing on recent clinical experience, promising technologies, and challenges to clinical success.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Springer New York
• Seitenzahl: 371
• Erscheinungstermin: 25. Oktober 2013
• Englisch
• ISBN-13: 9781461488095
• Artikelnr.: 43786676

Inhaltsangabe

Contents
Part I Immune Activation, Suppression and Manipulation of the Immune
Antitumor Response
Myeloid-Derived Suppressor Cells in Cancer.....Christos E. Kyriakopoulos,
Alberto J. Montero, and Claudia Marcela Diaz-Montero
The Role of B Cells in Shaping the Antitumor Immune Response......Yu Zhang,
Taylor H. Schreiber, and Joseph D. Rosenblatt
Heat-Shock Protein-Based Cancer Immunotherapy.....Taylor H. Schreiber
Activation of NK Cell Responses and Immunotherapy of Cancer......George J.
Weiner
Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated
mRNA Decay.....Eli Gilboa
Employing T Cell Homeostasis as an Antitumor Strategy.....Shawn M. Jensen,
Christopher C. Paustain, and Bernard A. Fox
Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells
Redirected with a Chimeric Antibody-Based Receptor.....Dinorah
Friedmann-Morvinski, Tova Waks, Assaf Marcus, and Zelig Eshhar
Part II Evolving Clinical Immunotherapeutic Strategies Immunotherapy in
Renal Cell Carcinoma.....Jennifer Cudris and Jaime R. Merchan Adoptive
T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic
Malignancies......Aaron P. Rapoport and Nadia Ijaz Bifunctional Antibodies:
Preclinical and Clinical Applications.....Casey W. Shuptrine and Louis M.
Weiner Clinical Development of Antibody-Fusion Proteins for Cancer
Therapy.....Kory L. Alderson, Amy K. Erbe, Margaret Boyden, and Paul M.
Sondel Immunologic Outcomes of Allogeneic Stem Cell Transplantation:
Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for
Future Therapy.....Lazaros J. Lekakis and Krishna V. Komanduri The Immune
System in Head and Neck Squamous Cell Carcinoma: Interactions and
Therapeutic Opportunities.....Paolo Serafini and Donald T. Weed T Cell
Co-regulatory Signals and Their Role in Cancer Therapy......Eitan R.
Friedman, Lynn Feun, Pasquale Benedetto, and Joseph D. Rosenblatt
Assessment of Immune Response in Biotherapy Trials and Clinical
Endpoints.....Theresa L. Whiteside Index