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Inhaltsangabe
1 Biochemical Pharmacology of GABA in CNS.- 1. Introduction.- 2. Effects of Compounds on the Metabolism of GABA in Vivo.- 3. Effects of Compounds on the Uptake and Release of GABA in Nervous Tissue.- 4. Effects of Compounds on the Interaction of GABA with Its Postsynaptic Receptor.- 5. Convulsant and Anticonvulsant Compounds Related to the GABA-Dependent Inhibitory Mechanism.- 6. Pharmacological Relationships Between Biogenic Amines and GABA.- 7. Effects of Compounds on GABA Metabolism During Ontogeny.- 8. Pharmacological Effects of GABA.- 9. Clinical Implications of Pharmacological Studies of GABA-Dependent Inhibition.- 10. References.- 2 Biochemistry of Glycine, Taurine, Glutamate, and Aspartate.- 1. Introduction.- 2. Chemistry.- 3. Occurrence.- 4. Metabolism.- 5. Transport.- 6. Conclusion.- 7. References.- 3 Amino Acid Receptors in CNS. I. GABA and Glycine in Spinal Cord.- 1. Introduction.- 2. Localization of Glycine and GABA in Spinal Cord.- 3. Release of GABA and Glycine.- 4. Pharmacology of Agonists.- 5. Pharmacology of Antagonists.- 6. Miscellaneous Agents.- 7. Amino Acids in Supraspinal Regions.- 8. Concluding Remarks.- 9. References.- 4 Amino Acid Receptors in CNS. II. GABA in Supraspinal Regions.- 1. Introduction.- 2. Inhibitory Action of GABA on Cortical Neurons.- 3. GABA Receptors in Supraspinal Regions Other Than Cerebral Cortex.- 4. Inhibitory Interneurons of Cerebral Cortex.- 5. Structure-Activity Relationships.- 6. References.- 5 Excitatory Amino Acid Receptors in the Central Nervous System.- 1. Introduction.- 2. Mechanisms of Glutamate Action.- 3. Excitation of Neurons by Analogues and Homologues of Glutamate.- 4. Receptors for Glutamate Uptake.- 5. Antagonists of Amino Acid-Induced Excitations.- 6. Antagonists of Glutamate Uptake.- 7. The Amino Acids as Physiological Synaptic Transmitters.- 8. References.- 6 Peptide Receptors in CNS.- 1. Introduction.- 2. Angiotensin II.- 3. Substance P and Related Peptides.- 4. Neurohypophyseal Hormones.- 5. Other Peptides.- 6. Conclusion.- 7. References.- 7 Amine and Amino Acid Receptors in Gastropod Neurons.- 1. Introduction.- 2. Electrophysiological Results from a Multireceptor System and Their Relationship to Methodology.- 3. Résumé of Receptor Pharmacology for Amines and Amino Acids.- 4. Analysis of Certain Drug-Receptor Characteristics in Molluscs.- 5. Conclusions.- 6. References.
1 Biochemical Pharmacology of GABA in CNS.- 1. Introduction.- 2. Effects of Compounds on the Metabolism of GABA in Vivo.- 3. Effects of Compounds on the Uptake and Release of GABA in Nervous Tissue.- 4. Effects of Compounds on the Interaction of GABA with Its Postsynaptic Receptor.- 5. Convulsant and Anticonvulsant Compounds Related to the GABA-Dependent Inhibitory Mechanism.- 6. Pharmacological Relationships Between Biogenic Amines and GABA.- 7. Effects of Compounds on GABA Metabolism During Ontogeny.- 8. Pharmacological Effects of GABA.- 9. Clinical Implications of Pharmacological Studies of GABA-Dependent Inhibition.- 10. References.- 2 Biochemistry of Glycine, Taurine, Glutamate, and Aspartate.- 1. Introduction.- 2. Chemistry.- 3. Occurrence.- 4. Metabolism.- 5. Transport.- 6. Conclusion.- 7. References.- 3 Amino Acid Receptors in CNS. I. GABA and Glycine in Spinal Cord.- 1. Introduction.- 2. Localization of Glycine and GABA in Spinal Cord.- 3. Release of GABA and Glycine.- 4. Pharmacology of Agonists.- 5. Pharmacology of Antagonists.- 6. Miscellaneous Agents.- 7. Amino Acids in Supraspinal Regions.- 8. Concluding Remarks.- 9. References.- 4 Amino Acid Receptors in CNS. II. GABA in Supraspinal Regions.- 1. Introduction.- 2. Inhibitory Action of GABA on Cortical Neurons.- 3. GABA Receptors in Supraspinal Regions Other Than Cerebral Cortex.- 4. Inhibitory Interneurons of Cerebral Cortex.- 5. Structure-Activity Relationships.- 6. References.- 5 Excitatory Amino Acid Receptors in the Central Nervous System.- 1. Introduction.- 2. Mechanisms of Glutamate Action.- 3. Excitation of Neurons by Analogues and Homologues of Glutamate.- 4. Receptors for Glutamate Uptake.- 5. Antagonists of Amino Acid-Induced Excitations.- 6. Antagonists of Glutamate Uptake.- 7. The Amino Acids as Physiological Synaptic Transmitters.- 8. References.- 6 Peptide Receptors in CNS.- 1. Introduction.- 2. Angiotensin II.- 3. Substance P and Related Peptides.- 4. Neurohypophyseal Hormones.- 5. Other Peptides.- 6. Conclusion.- 7. References.- 7 Amine and Amino Acid Receptors in Gastropod Neurons.- 1. Introduction.- 2. Electrophysiological Results from a Multireceptor System and Their Relationship to Methodology.- 3. Résumé of Receptor Pharmacology for Amines and Amino Acids.- 4. Analysis of Certain Drug-Receptor Characteristics in Molluscs.- 5. Conclusions.- 6. References.
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