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Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding…mehr
Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits.
Amyloid and Related Disorders presents an overview of the most
recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Aspects of the History and Nomenclature of Amyloid and Amyloidosis.-Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis.- AA Amyloidosis.- The Hereditary Amyloidoses.- Dialysis-Associated Amyloidosis.- Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System.- Cerebrovascular Amyloidoses.- Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis.- Light / Heavy Chain Deposition Disease as a Systemic Disorder.- Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits.- Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond.- Diagnosis of Amyloid Using Congo Red.- Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method.- Thioflavin T stain.- Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis.- Generic Diagnosis of Amyloid.- Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohistochemistry.- Amyloid Typing.-Options for Amyloid Typing in Renal Pathology.- Amyloid Typing: Immuno-Electron Microscopy.- Classification of Amyloidosis by Mass Spectrometry Based Proteomics.- Laboratory Support for Diagnosis of Amyloidosis.- Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias.- Laboratory Methods for the Diagnosis of Hereditary Amyloidoses.- Amyloidoses of the Kidney and Genitourinary Tract.- Cardiac Amyloidoses.- Amyloidosis of the Gastrointestinal Tract and Liver.- Peripheral Nerve Amyloidosis.- Clinical and Pathologic Issues in Patients with Amyloidosis.- Emerging Therapies for Amyloidosis.- Modern Therapies in AA Amyloidosis.- Medicolegal Issues of Amyloidosis.- Amyloidosis from the Patient’sPerspective.
Aspects of the History and Nomenclature of Amyloid and Amyloidosis.-Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis.- AA Amyloidosis.- The Hereditary Amyloidoses.- Dialysis-Associated Amyloidosis.- Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System.- Cerebrovascular Amyloidoses.- Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis.- Light / Heavy Chain Deposition Disease as a Systemic Disorder.- Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits.- Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond.- Diagnosis of Amyloid Using Congo Red.- Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method.- Thioflavin T stain.- Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis.- Generic Diagnosis of Amyloid.- Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohistochemistry.- Amyloid Typing.-Options for Amyloid Typing in Renal Pathology.- Amyloid Typing: Immuno-Electron Microscopy.- Classification of Amyloidosis by Mass Spectrometry Based Proteomics.- Laboratory Support for Diagnosis of Amyloidosis.- Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias.- Laboratory Methods for the Diagnosis of Hereditary Amyloidoses.- Amyloidoses of the Kidney and Genitourinary Tract.- Cardiac Amyloidoses.- Amyloidosis of the Gastrointestinal Tract and Liver.- Peripheral Nerve Amyloidosis.- Clinical and Pathologic Issues in Patients with Amyloidosis.- Emerging Therapies for Amyloidosis.- Modern Therapies in AA Amyloidosis.- Medicolegal Issues of Amyloidosis.- Amyloidosis from the Patient’s Perspective.
Aspects of the History and Nomenclature of Amyloid and Amyloidosis.-Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis.- AA Amyloidosis.- The Hereditary Amyloidoses.- Dialysis-Associated Amyloidosis.- Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System.- Cerebrovascular Amyloidoses.- Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis.- Light / Heavy Chain Deposition Disease as a Systemic Disorder.- Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits.- Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond.- Diagnosis of Amyloid Using Congo Red.- Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method.- Thioflavin T stain.- Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis.- Generic Diagnosis of Amyloid.- Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohistochemistry.- Amyloid Typing.-Options for Amyloid Typing in Renal Pathology.- Amyloid Typing: Immuno-Electron Microscopy.- Classification of Amyloidosis by Mass Spectrometry Based Proteomics.- Laboratory Support for Diagnosis of Amyloidosis.- Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias.- Laboratory Methods for the Diagnosis of Hereditary Amyloidoses.- Amyloidoses of the Kidney and Genitourinary Tract.- Cardiac Amyloidoses.- Amyloidosis of the Gastrointestinal Tract and Liver.- Peripheral Nerve Amyloidosis.- Clinical and Pathologic Issues in Patients with Amyloidosis.- Emerging Therapies for Amyloidosis.- Modern Therapies in AA Amyloidosis.- Medicolegal Issues of Amyloidosis.- Amyloidosis from the Patient’sPerspective.
Aspects of the History and Nomenclature of Amyloid and Amyloidosis.-Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis.- AA Amyloidosis.- The Hereditary Amyloidoses.- Dialysis-Associated Amyloidosis.- Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System.- Cerebrovascular Amyloidoses.- Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis.- Light / Heavy Chain Deposition Disease as a Systemic Disorder.- Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits.- Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond.- Diagnosis of Amyloid Using Congo Red.- Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method.- Thioflavin T stain.- Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis.- Generic Diagnosis of Amyloid.- Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohistochemistry.- Amyloid Typing.-Options for Amyloid Typing in Renal Pathology.- Amyloid Typing: Immuno-Electron Microscopy.- Classification of Amyloidosis by Mass Spectrometry Based Proteomics.- Laboratory Support for Diagnosis of Amyloidosis.- Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias.- Laboratory Methods for the Diagnosis of Hereditary Amyloidoses.- Amyloidoses of the Kidney and Genitourinary Tract.- Cardiac Amyloidoses.- Amyloidosis of the Gastrointestinal Tract and Liver.- Peripheral Nerve Amyloidosis.- Clinical and Pathologic Issues in Patients with Amyloidosis.- Emerging Therapies for Amyloidosis.- Modern Therapies in AA Amyloidosis.- Medicolegal Issues of Amyloidosis.- Amyloidosis from the Patient’s Perspective.
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