Uri Alon

An Introduction to Systems Biology (eBook, PDF)

Design Principles of Biological Circuits

• Format: PDF

Produktbeschreibung

Written for students and researchers in systems biology, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological networks, highlighting simple, recurring circuit elements that make up the regulation of cells and tissues.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 342
• Erscheinungstermin: 12. Juli 2019
• Englisch
• ISBN-13: 9781000001327
• Artikelnr.: 57123118

Autorenporträt

Uri Alon is the Abisch-Frenkel professor of systems biology at the Weizmann Institute of Science; https://www.weizmann.ac.il/mcb/UriAlon/homepage

Inhaltsangabe

Part 1: Network Motifs. 1. Transcription Networks: Basic Concepts. 2.
Autoregulation: A Network Motif. 3. The Feedforward Loop Network Motif. 4.
Temporal Programs and the Global Structure of Transcription Networks. 5.
Positive Feedback, Bistability, and Memory. 6. How to Build a Biological
Oscillator. Part 2: Robustness. 7. Kinetic Proofreading and Conformational
Proofreading. 8. Robust Signaling by Bifunctional Components. 9. Robustness
and Bacterial Chemotaxis. 10. Fold-Change Detection. 11. Dynamical
Compensation and Mutant Resistance in Tissues. 12. Robust Spatial
Patterning in Development. Part 3: Optimality. 13. Optimal Gene Circuit
Design. 14. Multi-Objective Optimality in Biology. 15. Modularity. Appendix
A: The Input Functions of Genes: Michaelis-Menten and Hill Equations.
Appendix B: Multi-Dimensional Input Functions. Appendix C: Graph Properties
of Transcription Networks. Appendix D. Noise in Gene Expression.