Androgens and Androgen Receptor (eBook, PDF)

Mechanisms, Functions, and Clini Applications
Redaktion: Chang, Chawnshang

• Format: PDF

Produktbeschreibung

Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications. Key topics covered include:

-The discovery and cloning of the androgen receptor; -Androgen receptor coregulators; -Androgen related genes and their consensus DNA response elements; -Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies; -Cross-talk to other signal transduction systems; -The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer.

This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 503
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781461511618
• Artikelnr.: 43988762

Autorenporträt

Chawnshang Chang, Ph.D., is the George Hoyt Whipple Distinguished Professor at the University of Rochester.

Inhaltsangabe

1. Androgen Biosynthesis and Degradation.- 2. Structural and Functional Analysis of the Androgen Receptor.- 3. Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity.- 4. Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors.- 5. Nongenomic Androgen Action.- 6. The Role of 5?-Reductase in Prostate Disease and Male Pattern Baldness.- 7. Natural Products and Environmental Androgens/Antiandrogens.- 8. Androgens in Prostate Cancer and Benign Prostatic Hypoplasia.- 9. The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications.- 10. Androgen Receptor with Expanded Poly-Q Length in SBMA (Kennedy Disease).- 11. Androgen Insensivity Syndrome (Testicular Feminization).- 12. Androgens in Immunology and Autoimmune Diseases.- 13. Androgens in Penile Development, Penile Erection and Erectile Dysfunction.- 14. Androgens and the Androgen Receptor in Male Sex Development and Fertility.- 15. Androgens and Brain Function: Behavioral Perspectives.- 16. Androgens, Skeletal Homeostasis, and Osteoporosis.- 17. Androgens and Coronary Artery Disease.- 18. Androgen Therapy in Nonendocrine Illnesses.- 19. Androgens and Androgen Receptor in Dermatology.- 20. Androgen Deficiency and Abnormality in Women.