Anthracycline Chemistry and Biology I (eBook, PDF)

Biological Occurence and Biosynthesis, Synthesis and Chemistry
Redaktion: Krohn, Karsten

• Format: PDF

Produktbeschreibung

With contributions by numerous experts

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 324
• Erscheinungstermin: 29. Oktober 2009
• Englisch
• ISBN-13: 9783540758150
• Artikelnr.: 53153083

Inhaltsangabe

Biological Occurence and Biosynthesis.- Naturally Occurring Anthracyclines.- Biosynthetic Anthracycline Variants.- Anthracycline Biosynthesis: Genes, Enzymes and Mechanisms.- Synthesis and Chemistry.- Synthesis of Enantiomerically Pure Anthracyclinones.- Combinatorial Synthesis of Linearly Condensed Polycyclic Compounds, Including Anthracyclinones, Through Tandem Diels-Alder Additions.- Fluorinated Anthracyclines.- Synthesis of the Sugar Moieties.- Nonnatural Glycosyl Anthraquinones as DNA Binding and Photocleaving Agents.- Syntheses of Anthracyclines and Fredericamycin A via Strong Base-Induced Cycloaddition Reaction of Homophthalic Anhydrides.

Rezensionen

From the reviews: "This book ... covers many different aspects of the origin, chemistry, and biosynthesis of one of the oldest but most important classes of anticancer agents. ... In summary, the book is nicely produced, very well edited, and should serve as a valuable source of information ... . This book will serve as an inspiration for scientists and students in the areas of chemistry, drug discovery, and biological evaluation. It should be an essential addition to institutional library collections ... ." (Waldemar Priebe, Journal of the American Chemical Society, Vol. 131 (23), 2009)