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Provides a comprehensive, fully updated reference book to the general principles and clinical applications of antimicrobials in veterinary medicine The sixth edition of Antimicrobial Therapy in Veterinary Medicine has been updated to reflect advances in the field, including new international contributors and a broader global outlook. It includes extensive knowledge of both general principles of mechanisms of antimicrobial drug action including specific classes of antimicrobial agents, as well as chapters dedicated to antimicrobial drug use in a wide range of animal species. As…mehr
Provides a comprehensive, fully updated reference book to the general principles and clinical applications of antimicrobials in veterinary medicine
The sixth edition of Antimicrobial Therapy in Veterinary Medicine has been updated to reflect advances in the field, including new international contributors and a broader global outlook. It includes extensive knowledge of both general principles of mechanisms of antimicrobial drug action including specific classes of antimicrobial agents, as well as chapters dedicated to antimicrobial drug use in a wide range of animal species. As antimicrobial resistance increases as a major global issue in both human and animal health, this book's renewed focus on antimicrobial stewardship in companion animals, in food animals, and on global aspects keeps it at the forefront of this vital field.
The Sixth Edition of this classic text offers:
Updates to every chapter, reflecting new developments and research, with a complete examination of the issues associated with antimicrobial resistance
A comprehensive reference for all aspects of antimicrobial use in veterinary medicine, encompassing theory and practice
A global perspective on antimicrobial therapy, with more international content than previous editions
A stronger emphasis on antimicrobial stewardship, with practical guidance for prescribing antimicrobial drugs
A companion website with tables and figures from the book available for download
Antimicrobial Therapy in Veterinary Medicine is an essential and accessible resource for veterinarians, veterinary students, scientists, and professionals in veterinary medicine and antimicrobial research and stewardship.
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Autorenporträt
The editors Patricia M. Dowling, DVM, MSc, DACVIM, DACVCP, is Professor of Veterinary Clinical Pharmacology at the Western College of Veterinary Medicine, University of Saskatchewan in Saskatoon, Saskatchewan, Canada. John F. Prescott, MA, VetMB, PhD, FCAHS, is University Professor Emeritus at the Ontario Veterinary College, University of Guelph in Guelph, Ontario, Canada. Keith E. Baptiste, BVMS, MSc, PhD, MRCVS, DACVIM, DECEIM, is Senior Veterinary Consultant in the Department of Veterinary Medicine at Danish Medicines Agency in Copenhagen, Denmark.
Inhaltsangabe
Contributors ix Preface xiii Acknowledgments xv Important Notice xvii List of Abbreviations xix Section I General Principles of Antimicrobial Therapy 1 1 Antimicrobial Drug Action and Interaction: An Introduction 3 John F. Prescott 2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 13 Joseph E. Rubin and Peter Damborg 3 Antimicrobial Resistance and Its Epidemiology 29 Marisa Haenni and Patrick Boerlin 4 Pharmacokinetics of Antimicrobials 51 Patricia M. Dowling 5 Pharmacodynamics of Antimicrobials 81 Andrew P. Woodward and Ted Whittem Copyrighted Material 6 Principles of Antimicrobial Drug Selection and Use 109 J. Scott Weese and Patricia M. Dowling Section II Classes of Antimicrobial Agents 119 7 Beta-lactam Antibiotics: Penam Penicillins 121 Laura Y. Hardefeldt and John F. Prescott 8 Beta-lactam Antibiotics: Cephalosporins 143 Laura Y. Hardefeldt and John F. Prescott 9 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 169 John F. Prescott and Laura Y. Hardefeldt 10 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 187 Patricia M. Dowling 11 Lincosamides, Pleuromutilins, and Streptogramins 203 Grazieli Maboni and Leticia Trevisan Gressler 12 Macrolides, Azalides, and Ketolides 223 John F. Prescott and Keith E. Baptiste 13 Aminoglycosides and Aminocyclitols 249 Patricia M. Dowling 14 Tetracyclines 273 Ronan J. J. Chapuis and Joe S. Smith 15 Chloramphenicol, Thiamphenicol, and Florfenicol 291 Patricia M. Dowling and Hélène Lardé 16 Sulfonamides, Diaminopyrimidines, and Their Combinations 305 Jennifer M. Reinhart and John F. Prescott 17 Fluoroquinolones 325 Patricia M. Dowling 18 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 345 Patricia M. Dowling and Keith E. Baptiste 19 Antifungal Chemotherapy 371 Keith E. Baptiste Section III Antimicrobial Stewardship 401 20 General Concepts in Antimicrobial Stewardship 403 Laura Y. Hardefeldt, J. Scott Weese, and Stephen W. Page 21 Global Aspects of One Health Antimicrobial Stewardship 425 Jeffrey T. LeJeune, Mark E. Caudell, Suzanne N. Eckford, and Stephen W. Page 22 Antimicrobial Stewardship in Companion Animals 445 Peter Damborg, J. Scott Weese, and John F. Prescott 23 Antimicrobial Stewardship in Food-producing Animals 459 David C. Speksnijder, Stephen W. Page, Jaap A. Wagenaar, and John F. Prescott 24 Antimicrobial Prophylaxis, Metaphylaxis, and the Treatment of Immunocompromised Patients 487 Diego E. Gomez and J. Scott Weese 25 Regulation of Antimicrobial Use in Animals 513 Alan Chicoine and Keith E. Baptiste 26 Antimicrobial Drug Residues in Foods of Animal Origin 527 Joe S. Smith and Patricia M. Dowling Section IV Antimicrobial Therapy in Selected Animal Species 545 27 Antimicrobial Drug Use in Horses 547 Keith E. Baptiste 28 Antimicrobial Therapy in Dogs and Cats 577 Jane E. Sykes and Peter Damborg 29 Antimicrobial Therapy in Beef Cattle 611 Michael D. Apley, Brian V. Lubbers, and Nora D. Schrag 30 Antimicrobial Therapy in Dairy Cattle 635 Sarah Wagner and Sarah Depenbrock 31 Antimicrobial Therapy in Sheep and Goats 655 Joe S. Smith and Amanda J. Kreuder 32 Antimicrobial Therapy in New World Camelids 671 Joe S. Smith 33 Antimicrobial Therapy in Swine 685 Ken Steen Pedersen 34 Antimicrobial Therapy in Poultry 697 Jenny A. Nicholds, David French, Daniel Parker, and Peter O'Kane 35 Antimicrobial Therapy in Companion Birds 721 Marike Visser 36 Antimicrobial Therapy in Rabbits, Rodents, and Ferrets 735 Colette L. Wheler and Patricia M. Dowling 37 Antimicrobial Therapy in Reptiles 767 J. Scott Weese 38 Antimicrobial Therapy in Zoo and Wildlife Species 791 Ellen Wiedner and Robert P. Hunter 39 Antimicrobial Therapy in Aquaculture 803 Patrick Whittaker, Timothy S. Kniffen, and Simon Otto 40 Antimicrobial Therapy in Honey Bees 819 Elemir Simko, Sarah Wood, and Ivanna V. Kozii Index 831
Contributors ix Preface xiii Acknowledgments xv Important Notice xvii List of Abbreviations xix Section I General Principles of Antimicrobial Therapy 1 1 Antimicrobial Drug Action and Interaction: An Introduction 3 John F. Prescott 2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 13 Joseph E. Rubin and Peter Damborg 3 Antimicrobial Resistance and Its Epidemiology 29 Marisa Haenni and Patrick Boerlin 4 Pharmacokinetics of Antimicrobials 51 Patricia M. Dowling 5 Pharmacodynamics of Antimicrobials 81 Andrew P. Woodward and Ted Whittem Copyrighted Material 6 Principles of Antimicrobial Drug Selection and Use 109 J. Scott Weese and Patricia M. Dowling Section II Classes of Antimicrobial Agents 119 7 Beta-lactam Antibiotics: Penam Penicillins 121 Laura Y. Hardefeldt and John F. Prescott 8 Beta-lactam Antibiotics: Cephalosporins 143 Laura Y. Hardefeldt and John F. Prescott 9 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 169 John F. Prescott and Laura Y. Hardefeldt 10 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 187 Patricia M. Dowling 11 Lincosamides, Pleuromutilins, and Streptogramins 203 Grazieli Maboni and Leticia Trevisan Gressler 12 Macrolides, Azalides, and Ketolides 223 John F. Prescott and Keith E. Baptiste 13 Aminoglycosides and Aminocyclitols 249 Patricia M. Dowling 14 Tetracyclines 273 Ronan J. J. Chapuis and Joe S. Smith 15 Chloramphenicol, Thiamphenicol, and Florfenicol 291 Patricia M. Dowling and Hélène Lardé 16 Sulfonamides, Diaminopyrimidines, and Their Combinations 305 Jennifer M. Reinhart and John F. Prescott 17 Fluoroquinolones 325 Patricia M. Dowling 18 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 345 Patricia M. Dowling and Keith E. Baptiste 19 Antifungal Chemotherapy 371 Keith E. Baptiste Section III Antimicrobial Stewardship 401 20 General Concepts in Antimicrobial Stewardship 403 Laura Y. Hardefeldt, J. Scott Weese, and Stephen W. Page 21 Global Aspects of One Health Antimicrobial Stewardship 425 Jeffrey T. LeJeune, Mark E. Caudell, Suzanne N. Eckford, and Stephen W. Page 22 Antimicrobial Stewardship in Companion Animals 445 Peter Damborg, J. Scott Weese, and John F. Prescott 23 Antimicrobial Stewardship in Food-producing Animals 459 David C. Speksnijder, Stephen W. Page, Jaap A. Wagenaar, and John F. Prescott 24 Antimicrobial Prophylaxis, Metaphylaxis, and the Treatment of Immunocompromised Patients 487 Diego E. Gomez and J. Scott Weese 25 Regulation of Antimicrobial Use in Animals 513 Alan Chicoine and Keith E. Baptiste 26 Antimicrobial Drug Residues in Foods of Animal Origin 527 Joe S. Smith and Patricia M. Dowling Section IV Antimicrobial Therapy in Selected Animal Species 545 27 Antimicrobial Drug Use in Horses 547 Keith E. Baptiste 28 Antimicrobial Therapy in Dogs and Cats 577 Jane E. Sykes and Peter Damborg 29 Antimicrobial Therapy in Beef Cattle 611 Michael D. Apley, Brian V. Lubbers, and Nora D. Schrag 30 Antimicrobial Therapy in Dairy Cattle 635 Sarah Wagner and Sarah Depenbrock 31 Antimicrobial Therapy in Sheep and Goats 655 Joe S. Smith and Amanda J. Kreuder 32 Antimicrobial Therapy in New World Camelids 671 Joe S. Smith 33 Antimicrobial Therapy in Swine 685 Ken Steen Pedersen 34 Antimicrobial Therapy in Poultry 697 Jenny A. Nicholds, David French, Daniel Parker, and Peter O'Kane 35 Antimicrobial Therapy in Companion Birds 721 Marike Visser 36 Antimicrobial Therapy in Rabbits, Rodents, and Ferrets 735 Colette L. Wheler and Patricia M. Dowling 37 Antimicrobial Therapy in Reptiles 767 J. Scott Weese 38 Antimicrobial Therapy in Zoo and Wildlife Species 791 Ellen Wiedner and Robert P. Hunter 39 Antimicrobial Therapy in Aquaculture 803 Patrick Whittaker, Timothy S. Kniffen, and Simon Otto 40 Antimicrobial Therapy in Honey Bees 819 Elemir Simko, Sarah Wood, and Ivanna V. Kozii Index 831
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