Aplastic Anemia (eBook, PDF)

Pathophysiology and Treatment
Redaktion: Schrezenmeier, Hubert

• Format: PDF

Produktbeschreibung

This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. As well as a detailed overview of the pathophysiology of the disease, the international team of authors cover all aspects of management, including the established approaches of bone marrow transplantation and immunosuppressive treatment, new approaches such as the use of hematopoietic growth factors and escalated immunosuppression, and controversial issues such as stem cell transplantation. Also included is an important international consensus document on treatment, and a final section concentrates on the inherited syndrome Fanconi's anemia. Detailed treatment guidelines are given, making this the definitive resource for hematologists and other clinicians involved in the management and supportive care of patients with aplastic anemia. Scientists interested in bone marrow failure will also find this an invaluable reference.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 11. November 1999
• Englisch
• ISBN-13: 9780511036255
• Artikelnr.: 38198109

Inhaltsangabe

Part I. Pathophysiology of Acquired Aplastic Anemia: 1. Stem cell defect in
aplastic anemia J. C. W. Marsh and N. G. Testa; 2. Cytokine abnormalities
in aplastic anemia S. Kojima; 3. Role of T-lymphocytes and apoptosis in
pathophysiology of aplastic anemia S. Nakao; 4. Role of apoptosis in
pathophysiology of aplastic anemia F. M. Gibson, N. J. Philpott, J. C. W.
Marsh and E. C. Gordon-Smith; 5. Interrelation between aplastic anemia and
paroxysmal nocturnal hemoglobinuria G. Socié, J.-Y. Mary, H. Schrezenmeier
and E. Gluckman; 6. Aplastic anemia and other clonal disorders A.
Raghavachar; Part II. Epidemiology and Clinical Features of Acquired
Aplastic Anemia: 7. Epidemiology and etiology of aplastic anemia H.
Heimpel; 8. Clinical presentation, natural course and prognostic factors P.
Marin-Fernandez; Part III. Treatment of Acquired Aplastic Anemia: 9.
Supportive treatment of patients with severe aplastic anemia P. Ljungman;
10. Immunosuppressive treatment of aplastic anemia A. Bacigalupo, H.
Schrezenmeier and A. Tichelli; 11. Role of cytokines in the treatment of
aplastic anemia H. Schrezenmeier; 12. HLA-identical sibling bone marrow
transplantation to treat severe aplastic anemia S. R. McCann, J. R.
Passweg, R. Storb and H. J. Deeg; 13. Alternative donor bone marrow
transplantation for severe acquired aplastic anemia J. M. Hows, J. V. Stone
and B. M. Camitta; 14. Treatment of children with acquired aplastic anemia
A. Locasciulli; 15. Long-term follow up of patients with aplastic anemia A.
Tichelli and G. Socié; 16. Guidelines for treatment of aplastic anemia
(international consensus document); Part IV. Fanconi's Anemia: 17. Clinical
features and diagnosis of Fanconi's anemia B. P. Alter; 18. Genetic basis
of Fanconi's anemia M. Buchwald and M. Carreau; 19. Treatment of Fanconi's
anemia E. Gluckman, G. Socié and P. Guardiola; 20. Genetic correction of
Fanconi's anemia J. M. Liu.