Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential (eBook, PDF)

Redaktion: Jana, Kuladip

• Format: PDF

Produktbeschreibung

This book comprehensively reviews the recent advancements in apoptosis research and evaluates its therapeutic targets and strategies in controlling various human diseases. The initial chapter presents the molecular components that regulate apoptosis and its importance for pathogenic processes. The subsequent chapters discuss the molecular mechanisms and signaling pathways involved in apoptosis induction and inhibition. The book also examines the role of mitochondria-driven apoptosis and therapeutic strategies for targeting mitochondria-mediated cell death. Further, the book discusses the role of apoptosis in different diseases, including neurodegeneration, cancer, diabetes, cardiovascular diseases, parasitic infections, autoimmune diseases, reproductive disorders, and infertility. Towards the end, the book outlines the recent advances in the field of apoptosis-based therapies and explores some highlights of a very active field of drug development. This book is useful for the researchers involved in designing and developing new drugs and drug targets for the treatment of different human diseases.

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Produktdetails

• Verlag: Springer Nature Singapore
• Seitenzahl: 457
• Erscheinungstermin: 20. Dezember 2024
• Englisch
• ISBN-13: 9789819779055
• Artikelnr.: 72636966

Autorenporträt

Dr. Kuladip Jana is presently serving as a Principal Scientist in the Division of Molecular Medicine and Scientist-In-Charge in Centre for Translational Animal Research, Bose Institute, Kolkata, India. Dr. Jana was trained as a Post-doctoral Research Associate in Molecular Endocrinology and Reproduction in relation with Aging/Alzheimer's disease in Garrison Institute on Aging, Texas Tech University Health Sciences Centre, Texas, U.S.A. and in Vaccine development against Cholera and Typhoid in National Institute of Cholera & Enteric Diseases, Kolkata, India and also in the field of Molecular signalling regulating cell growth/survival and death/apoptosis in breast/ cervical cancer cells in Saha Institute of Nuclear Physics, Kolkata after obtaining his M.S. and Ph.D. degree in Human Physiology (Molecular & Cellular Reproductive Biology & Endocrinology). Presently, Dr. Jana's laboratory focusing on Translational drug developmental Research in diverse directions. In the developmental work, Dr. Jana established a State-of-the-Art pre-clinical animal research facility "Centre for Translational Animal Research", in Bose Institute, Kolkata funded by DST, Govt. of India. Dr. Jana also developed a Non-surgical Chemical Sterilization drug for male animals in the course of his Ph.D. work. Dr. Jana serving as Advisor in Scientific Advisory Board of different Institutes as well as he is a Govt. of India approved Nominee in IAEC/IBSC/IHEC of different Institutes and Universities. Based on his research and fellowship training Dr. Jana received several awards, Fellowship and honours, such as: Young Investigator Award, 2011 (USA), Young Scientist Award, 2012 & 2014 (USA), Outstanding Scientist Award, 2015, Fellow of the Scholar Academic & Scientific Society (FSASS), Fellow of the National Environmental Science Academy (FNESA), Fellow of Reproduction & Endocrinology (FRE) etc. He is serving as an Editor and Editorial Board Member of more than Thirty-five (35) reputed International Journals. He has also authored many international research articles/book/book chapters. He is also a member of several learned Scientific Societies like, Society for Redox Biology & Medicine, USA, Science Advisory Board, USA etc. Dr. Jana is an Honorary Rosalind Member of the London Journal Press and he visited abroad to deliver invited lectures and Chaired Sessions in many conferences and workshops.

Inhaltsangabe

Chapter 1: Apoptosis: Intricate connections in cell death pathways and disease implications.- Chapter 2: Apoptosis: A Controlled Cell's Fate.- Chapter 3: Apoptosis: Novel insights into the role of death receptors and caspases in cell fate.- Chapter 4: Apoptosis: Mechanisms and Clinical Implications.- Chapter 5: Apoptosis and Mitochondria: Cell death mechanisms.- Chapter 6: Apoptosis: ER stress and Disease pathology.- Chapter 7: Apoptosis: Oxidative stress and Antioxidants.- Chapter 8: Caspase Independent Apoptosis: New Insights and Current Perspectives.- Chapter 9: Role of Apoptosis in Cancer: Therapeutic targets and strategies.- Chapter 10: Mechanisms of PANoptosis and its implications in cancer progression and treatment.- Chapter 11: Role of Apoptosis in Neurodegeneration: Therapeutic targets and strategies.-b Chapter 12: Role of Apoptosis in Diabetes: Therapeutic targets and strategies.- Chapter 13: Role of Apoptosis in Cardiovascular diseases: Therapeutic targets and strategies.- Chapter 14: Chapter 15: Role of Apoptosis in Parasitic infections: Therapeutic targets and strategies.- Chapter 15: Role of Apoptosis in Viral infections with special reference to Covid 19: Therapeutic targets and strategies.- Chapter 16: Role of Apoptosis in male Infertility: Therapeutic targets and strategies.- Chapter 17: Role of Apoptosis in aging: Therapeutic targets and strategies.- Chapter 18: Apoptosis: Natural product-derived small molecules as Therapeutics.- Chapter 19: Apoptosis-based therapeutics and inhibitors in clinical trials or in preclinical state.- Chapter 20: Apoptosis and cancer immunotherapy: Current mechanisms and emerging strategies.