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Arrowsmith tells the story of bright and scientifically minded Martin Arrowsmith of Elk Mills, Winnemac (the same fictional state in which several of Lewis's other novels are set), as he makes his way from a small town in the Midwest to the upper echelons of the scientific community at a prestigious foundation in New York City. Along the way he begins medical school. He becomes engaged to one woman, cheats on her ... Scholars have found eerie parallels to the COVID-19 crisis in the 1925 novel, and the many ethical dilemmas and challenges it presents.