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This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. . Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world . Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models . Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and…mehr
This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. . Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world . Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models . Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity . Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists . Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure
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Autorenporträt
J. Christopher States, PhD, is Professor, University Scholar and Vice Chair for Graduate Education in the Department of Pharmacology and Toxicology, and Associate Dean for Research in the University of Louisville School of Medicine, Louisville, Kentucky. He is a Past President of the Society of Toxicology Metals Specialty Section, on the editorial board of several leading journals, and regularly serves as a reviewer of manuscripts and National Institutes of Health grants. He has organized symposia and workshops and chaired sessions on arsenic exposure and toxicology at international conferences and published over 100 articles.
Inhaltsangabe
Contributors ix Preface xiii Part I Fundamentals of Arsenic Exposure and Metabolism 1 1 History of Arsenic as a Poison and a Medicinal Agent 3 Michael F. Hughes 2 Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils: Distribution, Nature, Origin, and Human Exposure Routes 23 David A. Polya and Michael Lawson 3 Remediation of Arsenic in Drinking Water 61 Cathleen J. Webb and Arden D. Davis 4 The Chemistry and Metabolism of Arsenic 81 David J. Thomas Part II Epidemiology and Disease Manifestations of Arsenic Exposure 111 5 Human Population Studies and Nutritional Intervention 113 Yu Chen and Fen Wu 6 Skin Manifestations of Chronic Arsenicosis 127 Nilendu Sarma 7 Lung Cancer and Other Pulmonary Diseases 137 Cara L. Sherwood and R. Clark Lantz 8 Bladder Cancer and Arsenic 163 Matthew K. Medeiros and A. Jay Gandolfi 9 Neurological Effects of Arsenic Exposure 193 Dominic B. Fee 10 Diabetes Mellitus 221 Miroslav Styblo and Christelle Douillet 11 Hepatotoxicity 249 Gavin E. Arteel 12 Genetic Epidemiology of Susceptibility to Arsenic Induced Diseases 267 Mayukh Banerjee and Ashok K. Giri Part III Mechanisms of Toxicity 289 13 Arsenic Interaction with Zinc Finger Motifs 291 Laurie G. Hudson, Karen L. Cooper, Susan R. Atlas, Brenee S. King and Ke Jian Liu 14 Role in Chemotherapy 315 Koren K. Mann and Maryse Lemaire 15 Genotoxicity 347 Ana Maria Salazar and Patricia Ostrosky Wegman 16 Arsenic and Signal Transduction 369 Ingrid L. Druwe and Richard R. Vaillancourt 17 Stem Cell Targeting and Alteration by Arsenic 397 Yuanyuan Xu, Erik J. Tokar and Michael P. Waalkes 18 Epigenetics and Arsenic Toxicity 421 Somnath Paul and Pritha Bhattacharjee Part IV Models for Arsenic Toxicology and Risk Assessment 439 19 Cancer Induced by Exposure to Arsenicals in Animals 441 Erik J. Tokar, Yuanyuan Xu and Michael P. Waalkes 20 Arsenic Induced Cardiovascular Disease 453 Aaron Barchowsky and J. Christopher States 21 Invertebrate Models in Arsenic Research: Past, Present, and Future 469 Iain L. Cartwright 22 Toxicokinetics and Pharmacokinetic Modeling of Arsenic 495 Elaina M. Kenyon and Harvey J. Clewell, III 23 Considerations for a Biologically Based Risk Assessment for Arsenic 511 Harvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager 24 Translating Experimental Data to Human Populations 535 J. Christopher States Index 549
Contributors ix Preface xiii Part I Fundamentals of Arsenic Exposure and Metabolism 1 1 History of Arsenic as a Poison and a Medicinal Agent 3 Michael F. Hughes 2 Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils: Distribution, Nature, Origin, and Human Exposure Routes 23 David A. Polya and Michael Lawson 3 Remediation of Arsenic in Drinking Water 61 Cathleen J. Webb and Arden D. Davis 4 The Chemistry and Metabolism of Arsenic 81 David J. Thomas Part II Epidemiology and Disease Manifestations of Arsenic Exposure 111 5 Human Population Studies and Nutritional Intervention 113 Yu Chen and Fen Wu 6 Skin Manifestations of Chronic Arsenicosis 127 Nilendu Sarma 7 Lung Cancer and Other Pulmonary Diseases 137 Cara L. Sherwood and R. Clark Lantz 8 Bladder Cancer and Arsenic 163 Matthew K. Medeiros and A. Jay Gandolfi 9 Neurological Effects of Arsenic Exposure 193 Dominic B. Fee 10 Diabetes Mellitus 221 Miroslav Styblo and Christelle Douillet 11 Hepatotoxicity 249 Gavin E. Arteel 12 Genetic Epidemiology of Susceptibility to Arsenic Induced Diseases 267 Mayukh Banerjee and Ashok K. Giri Part III Mechanisms of Toxicity 289 13 Arsenic Interaction with Zinc Finger Motifs 291 Laurie G. Hudson, Karen L. Cooper, Susan R. Atlas, Brenee S. King and Ke Jian Liu 14 Role in Chemotherapy 315 Koren K. Mann and Maryse Lemaire 15 Genotoxicity 347 Ana Maria Salazar and Patricia Ostrosky Wegman 16 Arsenic and Signal Transduction 369 Ingrid L. Druwe and Richard R. Vaillancourt 17 Stem Cell Targeting and Alteration by Arsenic 397 Yuanyuan Xu, Erik J. Tokar and Michael P. Waalkes 18 Epigenetics and Arsenic Toxicity 421 Somnath Paul and Pritha Bhattacharjee Part IV Models for Arsenic Toxicology and Risk Assessment 439 19 Cancer Induced by Exposure to Arsenicals in Animals 441 Erik J. Tokar, Yuanyuan Xu and Michael P. Waalkes 20 Arsenic Induced Cardiovascular Disease 453 Aaron Barchowsky and J. Christopher States 21 Invertebrate Models in Arsenic Research: Past, Present, and Future 469 Iain L. Cartwright 22 Toxicokinetics and Pharmacokinetic Modeling of Arsenic 495 Elaina M. Kenyon and Harvey J. Clewell, III 23 Considerations for a Biologically Based Risk Assessment for Arsenic 511 Harvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager 24 Translating Experimental Data to Human Populations 535 J. Christopher States Index 549
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