Academic Paper from the year 2024 in the subject Health - Physical Therapy / Occupational Therapy, , language: English, abstract: The most common form of arthritis is knee osteoarthritis, which is also referred to as wear-and-tear arthritis or degenerative arthritis. Most of the time, synovitis, subchondral bone loss, and osteoarthritis in the knees are the major signs of disease. Mechanical stress, inflammation, biochemical factors, hormonal changes, and getting older can all make knee osteoarthritis worse. The objective of this study is, to find the association of physical activity level and quality of life of the patients suffering from knee osteoarthritis. The analytical cross-sectional study approach was employed in the research. The group consisted of 278 persons with knee osteoarthritis out of them, few patients who satisfied the inclusion and exclusion criteria were recruited for the study. The research used the non-probability convenience selection approach. Information was received from private clinics, Services Hospital, and the Indus Hospital. The health-related quality of life was measured by SF36, while the physical activity level was measured using IPAQ. The present study has a positive finding that physical activity has an association with the quality of life in the knee osteoarthritis patient population. Nevertheless, such gross summary scores do not show its relation to general health, energy or fatigue based on IPAQ scores.