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Comprehensive and in-depth in its coverage, Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy reviews the recent progress in atherosclerosis research and offers cutting edge perspectives from experts in the field. Written by an international team of authors including leading physician-scientists, research experts and physicians, chapters are divided into four major sections, covering risk factors, cellular and molecular mechanisms, biochemical mechanisms and novel and future therapeutics. Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel…mehr
Comprehensive and in-depth in its coverage, Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy reviews the recent progress in atherosclerosis research and offers cutting edge perspectives from experts in the field. Written by an international team of authors including leading physician-scientists, research experts and physicians, chapters are divided into four major sections, covering risk factors, cellular and molecular mechanisms, biochemical mechanisms and novel and future therapeutics. Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy analyses recent progress from both conceptual and technological perspectives, suggesting new directions for atherosclerosis research and treatment for a growing population of researchers and clinicians in cardiovascular and related fields.
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Autorenporträt
Hong Wang is a professor of pharmacology at Temple University School of Medicine. Her research focuses on mechanisms of vascular disease, using research approaches includinggenetic cloning, molecular biology, protein chemistry and immunohistochemistry. Dr. Wang is the author of numerous publications in peer reviewed journals including Cardiovascular Research, Atherosclerosis, Blood, and Trends in Cardiovascular Medicine.
Inhaltsangabe
Contributors ix Foreword Joseph Loscalzo xv Preface Eric N. Olson xvii Section I: Risk Factors: Old and New 1 1 Lipoproteins 3 Ming-Lin Liu and Daniel J. Rader 2 Role of Dysglycemia in Atherosclerosis 15 David R. Clemmons 3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes 27 Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt 4 Inflammation 43 Caitlin Collins, Ellie Tzima, and Cam Patterson 5 Homocysteine: A Controversial Cardiovascular Risk Factor 53 Sanjana Dayal and Steven R. Lentz 6 Hypertension as a Risk Factor for Atherosclerosis 63 Annet Kirabo and David G. Harrison 7 The Genetics of Atherosclerosis: From Polymorphisms to Populations 77 Paul Johnson, Jack Kuritzky, and Marschall Runge 8 Life Style 93 Wayne E. Cascio Section II: Cellular Mechanisms 105 9 Endothelial Cells 107 G. Brandon Atkins, Gabriela Orasanu, and Mukesh K. Jain 10 Vascular Smooth Muscle Cells 117 Dario F. Riascos-Bernal and Nicholas E. S. Sibinga 11 Fibroblasts 129 Christopher Mack 12 Monocytes and Macrophages in Atherosclerosis 141 Shu Meng, Pu Fang, Xiaofeng Yang, and Hong Wang 13 Lymphocytes and Atherosclerosis 155 Anthony Virtue, Jietang Mai, Hong Wang, and Xiaofeng Yang 14 Stem Cells 173 Arjun Deb 15 Platelets 187 Jerry Ware and Adam Corken 16 Development and Use of Mouse Models of Atherosclerosis 197 Peggy Robinet and Jonathan D. Smith Section III: Molecular Mechanisms 207 17 Mechanisms of the Renin Angiotensin System Influencing Atherosclerosis 209 Hong Lu and Alan Daugherty 18 The Role of Caveolae and Caveolins in Atherogenesis 221 Victor Rizzo 19 Lysosomal Molecular Derangements in Atherosclerosis 235 Pin-Lan Li and Yang Zhang 20 C-Reactive Protein and Its Pathophysiological Roles in Atherosclerosis 247 Jianglin Fan, Jifeng Zhang, and Yuqing Eugene Chen 21 Paraoxonases 257 Srinivasa T. Reddy 22 Prostanoids, Their Receptors, and Atherogenesis 267 Domenico Praticò 23 Extracellular Phospholipases: Role in Inflammation and Atherosclerotic Cardiovascular Disease 279 Uwe J.F. Tietge 24 Apolipoprotein-B: The Crucial Protein of Atherogenic Lipoproteins 291 Kevin Jon Williams and Edward A. Fisher 25 HDL Receptor Scavenger Receptor BI: A Multipurpose Player in Cholesterol and Steroid Metabolism in Mice and Man 313 Ying Zhao, Menno Hoekstra, Suzanne J. A. Korporaal, Theo J. C. Van Berkel, and Miranda Van Eck 26 Pro and Anti-Inflammatory Cytokine Networks in Atherosclerosis 329 Michael V. Autieri 27 E CM and Atherosclerosis 343 Jie Du, Ying Wang, and Lixin Jia Section IV: Biochemical Mechanisms 353 28 Effects of Nitric Oxide on Atherosclerosis 355 Terrence Pong and Paul L. Huang 29 Protective Role of Heme Oxygenase-1 in Atherosclerosis 365 William Durante 30 Roles of Reactive Oxygen Species in Physiology and Pathology 379 Ping Song and Ming-Hui Zou 31 Hydrogen Sulfide: Role in Atherosclerosis, Mechanisms, and Therapeutic Potential 393 Elvis A. Peter, Jai Varma, and Christopher G. Kevil 32 Methylation and Atherosclerosis 405 Xin-Yu Xiong, Shu Meng, Xiaofeng Yang, and Hong Wang 33 Micromanaging Atherogenesis: Role of Micrornas in Atherosclerosis 423 Shusheng Wang and Chastain Anderson 34 Posttranslational Modifications: Role in Atherosclerosis 437 Justyna Fert-Bober, Ronald J. Holewinski, Joel A. Kooren, and Jennifer E. Van Eyk 35 Phosphorylation Regulation by Kinases and Phosphatases in Atherosclerosis 453 Katherine J. Elliott and Satoru Eguchi 36 Effect of MMPs on Cardiovasculature and Blood Flow: Role of Ros, Mitophagy, and Antioxidants 467 Thomas P. Vacek, Diana Neamtu, and Suresh C. Tyagi Section V: Clinical Management 479 37 Impact of Preventive Therapies on Clinical Management and Outcomes 481 Danny Eapen, Ahsan Achtchi, Reynaria Nieva, Kiran Valiani, Faresa Zarreen, Aalok Patel, Allen Dollar, Ijeoma Isiadinso, Susmita Parashar, Jefferson Baer, Kreton Mavromatis, and Laurence Sperling 38 Risk Stratification in Clinical Practice 495 Phil Mendys, Golsa Joodi, and Ross J. Simpson, Jr. 39 Molecular Imaging 503 Arun K. Thukkani and Farouc A. Jaffer 40 Pharmacological Therapy in the Management of Acute Coronary Syndromes 517 Andrew J. Sampson, Timir Paul, and George A. Stouffer 41 Targeted Molecular Therapeutics for Atherosclerosis 533 Lantz C. Mackey and Jonathon W. Homeister 42 High-Density Lipoprotein Therapies-Then and Now 545 Henry J. Pownall, Corina Rosales, Baiba K. Gillard, and Antonio M. Gotto, Jr. 43 Stem Cell Therapeutics 557 Mei Mei Wong and Qingbo Xu 44 Advances in Surgical Revascularization 567 Stephen J. Forest, Ahmed Khan, and Joseph J. DeRose, Jr. Index 579
Contributors ix Foreword Joseph Loscalzo xv Preface Eric N. Olson xvii Section I: Risk Factors: Old and New 1 1 Lipoproteins 3 Ming-Lin Liu and Daniel J. Rader 2 Role of Dysglycemia in Atherosclerosis 15 David R. Clemmons 3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes 27 Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt 4 Inflammation 43 Caitlin Collins, Ellie Tzima, and Cam Patterson 5 Homocysteine: A Controversial Cardiovascular Risk Factor 53 Sanjana Dayal and Steven R. Lentz 6 Hypertension as a Risk Factor for Atherosclerosis 63 Annet Kirabo and David G. Harrison 7 The Genetics of Atherosclerosis: From Polymorphisms to Populations 77 Paul Johnson, Jack Kuritzky, and Marschall Runge 8 Life Style 93 Wayne E. Cascio Section II: Cellular Mechanisms 105 9 Endothelial Cells 107 G. Brandon Atkins, Gabriela Orasanu, and Mukesh K. Jain 10 Vascular Smooth Muscle Cells 117 Dario F. Riascos-Bernal and Nicholas E. S. Sibinga 11 Fibroblasts 129 Christopher Mack 12 Monocytes and Macrophages in Atherosclerosis 141 Shu Meng, Pu Fang, Xiaofeng Yang, and Hong Wang 13 Lymphocytes and Atherosclerosis 155 Anthony Virtue, Jietang Mai, Hong Wang, and Xiaofeng Yang 14 Stem Cells 173 Arjun Deb 15 Platelets 187 Jerry Ware and Adam Corken 16 Development and Use of Mouse Models of Atherosclerosis 197 Peggy Robinet and Jonathan D. Smith Section III: Molecular Mechanisms 207 17 Mechanisms of the Renin Angiotensin System Influencing Atherosclerosis 209 Hong Lu and Alan Daugherty 18 The Role of Caveolae and Caveolins in Atherogenesis 221 Victor Rizzo 19 Lysosomal Molecular Derangements in Atherosclerosis 235 Pin-Lan Li and Yang Zhang 20 C-Reactive Protein and Its Pathophysiological Roles in Atherosclerosis 247 Jianglin Fan, Jifeng Zhang, and Yuqing Eugene Chen 21 Paraoxonases 257 Srinivasa T. Reddy 22 Prostanoids, Their Receptors, and Atherogenesis 267 Domenico Praticò 23 Extracellular Phospholipases: Role in Inflammation and Atherosclerotic Cardiovascular Disease 279 Uwe J.F. Tietge 24 Apolipoprotein-B: The Crucial Protein of Atherogenic Lipoproteins 291 Kevin Jon Williams and Edward A. Fisher 25 HDL Receptor Scavenger Receptor BI: A Multipurpose Player in Cholesterol and Steroid Metabolism in Mice and Man 313 Ying Zhao, Menno Hoekstra, Suzanne J. A. Korporaal, Theo J. C. Van Berkel, and Miranda Van Eck 26 Pro and Anti-Inflammatory Cytokine Networks in Atherosclerosis 329 Michael V. Autieri 27 E CM and Atherosclerosis 343 Jie Du, Ying Wang, and Lixin Jia Section IV: Biochemical Mechanisms 353 28 Effects of Nitric Oxide on Atherosclerosis 355 Terrence Pong and Paul L. Huang 29 Protective Role of Heme Oxygenase-1 in Atherosclerosis 365 William Durante 30 Roles of Reactive Oxygen Species in Physiology and Pathology 379 Ping Song and Ming-Hui Zou 31 Hydrogen Sulfide: Role in Atherosclerosis, Mechanisms, and Therapeutic Potential 393 Elvis A. Peter, Jai Varma, and Christopher G. Kevil 32 Methylation and Atherosclerosis 405 Xin-Yu Xiong, Shu Meng, Xiaofeng Yang, and Hong Wang 33 Micromanaging Atherogenesis: Role of Micrornas in Atherosclerosis 423 Shusheng Wang and Chastain Anderson 34 Posttranslational Modifications: Role in Atherosclerosis 437 Justyna Fert-Bober, Ronald J. Holewinski, Joel A. Kooren, and Jennifer E. Van Eyk 35 Phosphorylation Regulation by Kinases and Phosphatases in Atherosclerosis 453 Katherine J. Elliott and Satoru Eguchi 36 Effect of MMPs on Cardiovasculature and Blood Flow: Role of Ros, Mitophagy, and Antioxidants 467 Thomas P. Vacek, Diana Neamtu, and Suresh C. Tyagi Section V: Clinical Management 479 37 Impact of Preventive Therapies on Clinical Management and Outcomes 481 Danny Eapen, Ahsan Achtchi, Reynaria Nieva, Kiran Valiani, Faresa Zarreen, Aalok Patel, Allen Dollar, Ijeoma Isiadinso, Susmita Parashar, Jefferson Baer, Kreton Mavromatis, and Laurence Sperling 38 Risk Stratification in Clinical Practice 495 Phil Mendys, Golsa Joodi, and Ross J. Simpson, Jr. 39 Molecular Imaging 503 Arun K. Thukkani and Farouc A. Jaffer 40 Pharmacological Therapy in the Management of Acute Coronary Syndromes 517 Andrew J. Sampson, Timir Paul, and George A. Stouffer 41 Targeted Molecular Therapeutics for Atherosclerosis 533 Lantz C. Mackey and Jonathon W. Homeister 42 High-Density Lipoprotein Therapies-Then and Now 545 Henry J. Pownall, Corina Rosales, Baiba K. Gillard, and Antonio M. Gotto, Jr. 43 Stem Cell Therapeutics 557 Mei Mei Wong and Qingbo Xu 44 Advances in Surgical Revascularization 567 Stephen J. Forest, Ahmed Khan, and Joseph J. DeRose, Jr. Index 579
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