Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (eBook, ePUB)

Volume 6- Regulation of Autophagy and Selective Autophagy
Redaktion: Hayat, M. A.

• Format: ePub

Produktbeschreibung

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus.

The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored.

This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.

Volumes in the Series

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 338
• Erscheinungstermin: 31. Dezember 2014
• Englisch
• ISBN-13: 9780128010532
• Artikelnr.: 42330750

Autorenporträt

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Inhaltsangabe

Autophagy and Molecular MechanismsIntroduction1. Regulation of autophagy by amino acids2. Regulation of autophagy by amino acid starvation involving ca2+3. Regulation of autophagy by micrornas4. Mechanisms of cross-talk between intracellular protein degradation pathways5. Cross-talk between autophagy and apoptosis in adipose tissue: role of ghrelinAutophagy and Intracellular Pathogens6. Intracellular pathogen invasion of the host cells: role of the alfa-hemolysin induced autophagy7. Modulation of autophagy by herpesvirus proteins8. Autophagy induced by varicella-zoster virus and the maintenance of cellular homeostasis9. Autophagy and hepatitis b virusAutophagy and Immunity10. Toll-like receptors serve as activators for autophagy in macrophages helping to facilitate innate immunity11. Autophagy in antigen processing for mhc presentation to t cells12. Autophagy controls the production and secretion of il-1ß: underlying mechanisms13. Role of autophagy in p2x7 receptor-mediated maturation and unconventional secretion of il-1ß in microglia14. Autophagy restricts interleukin-1ß signaling via regulation of p62 stability15. The role of autophagy in the thymic epitheliumAutophagy: General Applications 16. The role of autophagy receptors in mitophagy17. The role of parkin and pink1 in mitochondrial quality control18. Autophagy degrades endocytosed gap junctions